Mutagenesis approaches to deduce structure-function relationships in terpene synthases (Q35163464)

6 August 2017

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title

Mutagenesis approaches to deduce structure-function relationships in terpene synthases (English)

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6 August 2017

Michael J R Segura

1

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PubMed ID

12828369

6 August 2017

Beth E Jackson

series ordinal

2

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PubMed ID

12828369

6 August 2017

Seiichi P T Matsuda

series ordinal

3

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6 August 2017

1 June 2003

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6 August 2017

Natural Product Reports

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6 August 2017

20

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6 August 2017

3

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6 August 2017

304-317

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Plant terpenoid synthases: molecular biology and phylogenetic analysis

6 August 2017

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Molecular scaffolds for chemical wizardry: learning nature's rules for terpene cyclases

21 January 2018

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The biosynthesis of C5-C25 terpenoid compounds

21 January 2018

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Carotenoid biosynthesis and biotechnological application

21 January 2018

1 reference

Functional cloning of an Arabidopsis thaliana cDNA encoding cycloeucalenol cycloisomerase.

21 January 2018

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Cloning, expression, and sequencing of squalene-hopene cyclase, a key enzyme in triterpenoid metabolism

21 January 2018

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Squalene-hopene cyclase: catalytic mechanism and substrate recognition

21 January 2018

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Structure and function of a squalene cyclase

21 January 2018

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The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution

21 January 2018

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Formation of sterols by the action of 2,3-oxidosqualene-sterol cyclase on the factitious substrates 2,3:22,23-dioxidosqualene and 2,3-oxido-22,23-dihydrosqualene

21 January 2018

1 reference

Studies on the Substrate Binding Segments and Catalytic Action of Lanosterol Synthase. Affinity Labeling with Carbocations Derived from Mechanism-Based Analogs of 2,3-Oxidosqualene and Site-Directed Mutagenesis Probes

21 January 2018

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Inhibitors of squalene biosynthesis and metabolism

21 January 2018

1 reference

Sterol biosynthesis via cycloartenol and other biochemical features related to photosynthetic phyla in the amoeba Naegleria lovaniensis and Naegleria gruberi

21 January 2018

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Sterol biosynthesis de nova via cycloartenol by the soil amoeba Acanthamoeba polyphaga

21 January 2018

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Sterol phylogenesis and algal evolution

21 January 2018

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Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen

21 January 2018

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Conversion of a plant oxidosqualene-cycloartenol synthase to an oxidosqualene-lanosterol cyclase by random mutagenesis

21 January 2018

1 reference

Molecular cloning of cDNA encoding rat 2,3-oxidosqualene: lanosterol cyclase.

21 January 2018

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Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase cDNA

21 January 2018

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Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library

21 January 2018

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Molecular cloning of cDNA encoding human lanosterol synthase

21 January 2018

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Cloning and heterologous expression of the Trypanosoma brucei lanosterol synthase gene.

21 January 2018

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Sequence of the Candida albicans erg7 gene.

21 January 2018

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Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase

21 January 2018

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Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae

21 January 2018

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Molecular cloning of a Schizosaccharomyces pombe cDNA encoding lanosterol synthase and investigation of conserved tryptophan residues

21 January 2018

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Molecular cloning, expression, and site-directed mutations of oxidosqualene cyclase from Cephalosporium caerulens

21 January 2018

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Subcellular localization of oxidosqualene cyclases from Arabidopsis thaliana, Trypanosoma cruzi, and Pneumocystis carinii expressed in yeast

21 January 2018

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Molecular cloning of pea cDNA encoding cycloartenol synthase and its functional expression in yeast

21 January 2018

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Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants

21 January 2018

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Molecular cloning and characterization of a cDNA for Glycyrrhiza glabra cycloartenol synthase.

21 January 2018

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A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots

21 January 2018

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Steric bulk at position 454 in Saccharomyces cerevisiae lanosterol synthase influences B-ring formation but not deprotonation

21 January 2018

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Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol

21 January 2018

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Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides

21 January 2018

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Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology

21 January 2018

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Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase

21 January 2018

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Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti

21 January 2018

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X-ray crystal structures of D100E trichodiene synthase and its pyrophosphate complex reveal the basis for terpene product diversity

21 January 2018

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Trichodiene synthase. Identification of active site residues by site-directed mutagenesis

21 January 2018

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Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides

21 January 2018

1 reference

Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319

21 January 2018

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Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene

21 January 2018

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Trichodiene synthase. Probing the role of the highly conserved aspartate-rich region by site-directed mutagenesis.

21 January 2018

1 reference

Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition—elimination reactions

21 January 2018

1 reference

Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp

21 January 2018

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Sesquiterpene Progenitor, Germacrene A: An Alarm Pheromone in Aphids

21 January 2018

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(+)-Germacrene A biosynthesis . The committed step in the biosynthesis of bitter sesquiterpene lactones in chicory

21 January 2018

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Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis

21 January 2018

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Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases delta-selinene synthase and gamma-humulene synthase

21 January 2018

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Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes

21 January 2018

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Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis

21 January 2018

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Enzyme Mechanisms for Polycyclic Triterpene Formation

21 January 2018

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Biosynthesis of friedelane and quinonemethide triterpenoids is compartmentalized in Maytenus aquifolium and Salacia campestris

21 January 2018

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Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution

21 January 2018

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Sterol Biosynthesis in Euglena gracilis Z.. Sterol Precursors in Light-Grown and Dark-Grown Euglena gracilis Z

21 January 2018

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Steric bulk at cycloartenol synthase position 481 influences cyclization and deprotonation

21 January 2018

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Cloning and characterization of the Dictyostelium discoideum cycloartenol synthase cDNA

21 January 2018

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Directed evolution to generate cycloartenol synthase mutants that produce lanosterol

21 January 2018

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Biosynthetic studies of marine lipids. 25. Biosynthesis of .DELTA.9(11)- and .DELTA.7-sterols and saponins in sea cucumbers

21 January 2018

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Oxidosqualene Cyclase Residues that Promote Formation of Cycloartenol, Lanosterol, and Parkeol We are grateful to Bridget M. Joubert for advice regarding mutagenesis. We thank Elizabeth A. Hart for an authentic parkeol standard, and for chromatograp

21 January 2018

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Trypanosome and animal lanosterol synthases use different catalytic motifs

21 January 2018

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In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes

21 January 2018

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21 January 2018

Natural sesquiterpenoids

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The structures of trichodiol and trichodiene

21 January 2018

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Pentalenene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate

21 January 2018

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Managing and manipulating carbocations in biology: terpenoid cyclase structure and mechanism

21 January 2018

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Isolation of the elusive (−)-germacrene-a from the gorgonian, eunicea mammosa chemistry of coelenterates. XVIII.

21 January 2018

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5-epi-aristolochene is a common precursor of the sesquiterpenoid phytoalexins capsidiol and debneyol

21 January 2018

1 reference

https://api.fatcat.wiki/v0/release/upx5dtrabzcflosvqdpy5wrjze

21 January 2018

Identifiers

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Fatcat ID

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30 July 2022

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