Phospholamban: a crucial regulator of cardiac contractility (Q35167969)

6 August 2017

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title

Phospholamban: a crucial regulator of cardiac contractility (English)

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6 August 2017

David H MacLennan

1

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PubMed ID

12838339

6 August 2017

Evangelia G Kranias

series ordinal

2

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6 August 2017

1 July 2003

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Nature Reviews Molecular Cell Biology

6 August 2017

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6 August 2017

4

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6 August 2017

7

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6 August 2017

566-577

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https://scigraph.springernature.com/pub.10.1038/nrm1151

6 August 2017

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From epinephrine to cyclic AMP.

31 March 2020

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Calcium and cardiac rhythms: physiological and pathophysiological

31 March 2020

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Phospholamban: protein structure, mechanism of action, and role in cardiac function

31 March 2020

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Modeling of the inhibitory interaction of phospholamban with the Ca2+ ATPase.

31 March 2020

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Phospholamban inhibitory function is activated by depolymerization

31 March 2020

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Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo

31 March 2020

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The transgenic expression of highly inhibitory monomeric forms of phospholamban in mouse heart impairs cardiac contractility

31 March 2020

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Superinhibition of sarcoplasmic reticulum function by phospholamban induces cardiac contractile failure

31 March 2020

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Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation

31 March 2020

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Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice

31 March 2020

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Phospholamban: a prominent regulator of myocardial contractility

31 March 2020

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Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy

31 March 2020

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Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractility

31 March 2020

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Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery

31 March 2020

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Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban

31 March 2020

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Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

31 March 2020

1 reference

Cyclic adenosine 3',5'-monophosphate-dependent protein kinase stimulation of calcium uptake by canine cardiac microsomes

31 March 2020

1 reference

Discovery of phospholamban. A personal history

31 March 2020

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An investigation of the mechanism of inhibition of the Ca(2+)-ATPase by phospholamban

31 March 2020

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Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart

31 March 2020

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Phosphorylation of C-protein, troponin I and phospholamban in isolated rabbit hearts

31 March 2020

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Immunodetection of phosphorylation sites gives new insights into the mechanisms underlying phospholamban phosphorylation in the intact heart

31 March 2020

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Complete complementary DNA-derived amino acid sequence of canine cardiac phospholamban

31 March 2020

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Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease

31 March 2020

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Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase

31 March 2020

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Solution structure of the cytoplasmic domain of phopholamban: phosphorylation leads to a local perturbation in secondary structure

31 March 2020

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Structure of the 1-36 amino-terminal fragment of human phospholamban by nuclear magnetic resonance and modeling of the phospholamban pentamer

31 March 2020

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Structure and orientation of sarcolipin in lipid environments

31 March 2020

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Nature and site of phospholamban regulation of the Ca2+ pump of sarcoplasmic reticulum

31 March 2020

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Structural changes in the calcium pump accompanying the dissociation of calcium

31 March 2020

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Transmembrane helix M6 in sarco(endo)plasmic reticulum Ca(2+)-ATPase forms a functional interaction site with phospholamban. Evidence for physical interactions at other sites

31 March 2020

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Phospholamban regulates the Ca2+-ATPase through intramembrane interactions

31 March 2020

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Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel

31 March 2020

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A leucine zipper stabilizes the pentameric membrane domain of phospholamban and forms a coiled-coil pore structure

31 March 2020

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Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban

31 March 2020

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Functional Co-expression of the canine cardiac Ca2+ pump and phospholamban in Spodoptera frugiperda (Sf21) cells reveals new insights on ATPase regulation

31 March 2020

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Phospholamban domain Ib mutations influence functional interactions with the Ca2+-ATPase isoform of cardiac sarcoplasmic reticulum

31 March 2020

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The mechanism of Ca2+ transport by sarco(endo)plasmic reticulum Ca2+-ATPases

31 March 2020

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Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution

31 March 2020

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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

31 March 2020

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A structural model of the complex formed by phospholamban and the calcium pump of sarcoplasmic reticulum obtained by molecular mechanics

31 March 2020

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Physical interactions between phospholamban and sarco(endo)plasmic reticulum Ca2+-ATPases are dissociated by elevated Ca2+, but not by phospholamban phosphorylation, vanadate, or thapsigargin, and are enhanced by ATP.

31 March 2020

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Phospholamban gene dosage effects in the mammalian heart

31 March 2020

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Effect of ablation of phospholamban on dynamics of cardiac myocyte contraction and intracellular Ca2+

31 March 2020

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Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts

31 March 2020

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The Enhanced Contractility of the Phospholamban-deficient Mouse Heart Persists with Aging

31 March 2020

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Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis

31 March 2020

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Ablation of PLB exacerbates ischemic injury to a lesser extent in female than male mice: protective role of NO.

31 March 2020

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Targeted ablation of the phospholamban gene is associated with a marked decrease in sensitivity in aortic smooth muscle

31 March 2020

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Phospholamban ablation enhances relaxation in the murine soleus

31 March 2020

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Phospholamban regulation of bladder contractility: evidence from gene-altered mouse models

31 March 2020

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Phospholamban is present in endothelial cells and modulates endothelium-dependent relaxation. Evidence from phospholamban gene-ablated mice

31 March 2020

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Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality

31 March 2020

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Gender influences on sarcoplasmic reticulum Ca2+-handling in failing human myocardium

31 March 2020

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Maximal inhibition of SERCA2 Ca(2+) affinity by phospholamban in transgenic hearts overexpressing a non-phosphorylatable form of phospholamban

31 March 2020

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Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure

31 March 2020

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Transgenic approaches to define the functional role of dual site phospholamban phosphorylation

31 March 2020

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A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta -agonists

31 March 2020

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Time course and mechanisms of phosphorylation of phospholamban residues in ischemia-reperfused rat hearts. Dissociation of phospholamban phosphorylation pathways

31 March 2020

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Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes

31 March 2020

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Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure

31 March 2020

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The sarcoplasmic reticulum and the Na+/Ca2+ exchanger both contribute to the Ca2+ transient of failing human ventricular myocytes

31 March 2020

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Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium

31 March 2020

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Unchanged protein levels of SERCA II and phospholamban but reduced Ca2+ uptake and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts

31 March 2020

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Frequency dependent force generation correlates with sarcoplasmic calcium ATPase activity in human myocardium

31 March 2020

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Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium

31 March 2020

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Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy

31 March 2020

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Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation

31 March 2020

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Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients

31 March 2020

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Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a

31 March 2020

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Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure

31 March 2020

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Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure

31 March 2020

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Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation

31 March 2020

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Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts

31 March 2020

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Adenovirus-based phospholamban antisense expression as a novel approach to improve cardiac contractile dysfunction: comparison of a constitutive viral versus an endothelin-1-responsive cardiac promoter

31 March 2020

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Targeting phospholamban by gene transfer in human heart failure

31 March 2020

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Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation

31 March 2020

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Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy

31 March 2020

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Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy

31 March 2020

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AKAP-mediated targeting of protein kinase a regulates contractility in cardiac myocytes

31 March 2020

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Functional effects of endothelin and regulation of endothelin receptors in isolated human nonfailing and failing myocardium.

31 March 2020

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31 March 2020

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Structural aspects of troponin-tropomyosin regulation of skeletal muscle contraction

31 March 2020

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Ca2+ signalling and muscle disease

31 March 2020

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Malignant hyperthermia and central core disease: disorders of Ca2+ release channels

31 March 2020

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Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia

31 March 2020

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Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia

31 March 2020

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Absence of calsequestrin 2 causes severe forms of catecholaminergic polymorphic ventricular tachycardia

31 March 2020

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Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease

31 March 2020

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Sarcolipin, the "proteolipid" of skeletal muscle sarcoplasmic reticulum, is a unique, amphipathic, 31-residue peptide

31 March 2020

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Corticosteroids decrease mRNA levels of SERCA pumps, whereas they increase sarcolipin mRNA in the rat diaphragm

31 March 2020

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Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling.

31 March 2020

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Sarcolipin overexpression in rat slow twitch muscle inhibits sarcoplasmic reticulum Ca2+ uptake and impairs contractile function.

31 March 2020

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Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)

31 March 2020

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Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban

31 March 2020

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Energy Interconversion by the Ca2+-Dependent ATPase of the Sarcoplasmic Reticulum

31 March 2020

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Structure and function of the calcium pump

31 March 2020

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Mutation and phosphorylation change the oligomeric structure of phospholamban in lipid bilayers

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1151

1 reference

6 August 2017

1 reference

PubMed ID

12838339