Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development (Q35168016)

6 August 2017

title

Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development (English)

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6 August 2017

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Zuoxiang Xiao

1

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6 August 2017

Abdiaziz S Mohamood

2

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6 August 2017

Sophia Uddin

3

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6 August 2017

Rachel Gutfreund

4

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6 August 2017

Chiaki Nakata

5

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6 August 2017

Andrew Marshall

6

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6 August 2017

Hiroaki Kimura

7

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6 August 2017

Patrizio Caturegli

8

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6 August 2017

Karl L Womer

9

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6 August 2017

Yanfei Huang

10

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6 August 2017

Chunfa Jie

11

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6 August 2017

Shukti Chakravarti

12

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6 August 2017

Jonathan P Schneck

13

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6 August 2017

Hideo Yagita

14

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6 August 2017

Abdel Rahim A Hamad

15

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6 August 2017

language of work or name

English

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publication date

15 June 2011

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The American Journal of Pathology

6 August 2017

published in

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6 August 2017

volume

179

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6 August 2017

issue

2

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6 August 2017

page(s)

725-732

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Analysis of gene profile, steady state proliferation and apoptosis of double-negative T cells in the periphery and gut epithelium provides new insights into the biological functions of the Fas pathway.

6 August 2017

cites work

1 reference

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Fas-mediated apoptosis regulates the composition of peripheral alphabeta T cell repertoire by constitutively purging out double negative T cells

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Protection from autoimmune diabetes and T-cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologically

13 July 2018

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Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity

13 July 2018

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13 July 2018

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Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

13 July 2018

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T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis

13 July 2018

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13 July 2018

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Contribution of Fas to diabetes development

13 July 2018

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Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

13 July 2018

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13 July 2018

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IL-10 deficiency does not inhibit insulitis and accelerates cyclophosphamide-induced diabetes in the nonobese diabetic mouse.

13 July 2018

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Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

13 July 2018

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13 July 2018

Fas ligand, death gene.

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Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway.

13 July 2018

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Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment

13 July 2018

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Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes

13 July 2018

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13 July 2018

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Polymorphism of murine Fas ligand that affects the biological activity

13 July 2018

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T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions.

13 July 2018

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13 July 2018

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Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

13 July 2018

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Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

13 July 2018

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Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

13 July 2018

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Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes

27 September 2018

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Fas ligation induces IL-1beta-dependent maturation and IL-1beta-independent survival of dendritic cells: different roles of ERK and NF-kappaB signaling pathways.

27 September 2018

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Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation.

27 September 2018

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Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory res

27 September 2018

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27 September 2018

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Inhibition of autoimmune diabetes by Fas ligand: the paradox is solved

27 September 2018

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12 December 2020

Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation

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12 December 2020

Fas/Fas ligand interactions play an essential role in the initiation of murine autoimmune diabetes

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12 December 2020

Cutting edge: a novel role for Fas ligand in facilitating antigen acquisition by dendritic cells

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12 December 2020

Following a diabetogenic T cell from genesis through pathogenesis

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12 December 2020

Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse

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12 December 2020

The role of Fas in autoimmune diabetes

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12 December 2020

Evidence that beta cell death in the nonobese diabetic mouse is Fas independent

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12 December 2020

Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines

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12 December 2020

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies

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Intravenous transfusion of BCR-activated B cells protects NOD mice from type 1 diabetes in an IL-10-dependent manner

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Combination therapies for type 1 diabetes: why not now?

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10.1016/J.AJPATH.2011.04.016

Identifiers

DOI

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6 August 2017

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6 August 2017

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