Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C. (Q35183019)

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28 February 2020

title

Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C (English)

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28 February 2020

5

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28 February 2020

Jennifer C Lee

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author name string

James M Gruschus

1

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28 February 2020

Zhiping Jiang

2

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28 February 2020

Thai Leong Yap

3

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28 February 2020

Stephanie A Hill

4

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28 February 2020

Grzegorz Piszczek

6

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28 February 2020

Ellen Sidransky

7

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28 February 2020

language of work or name

English

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publication date

17 January 2015

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Biochemical and Biophysical Research Communications

28 February 2020

published in

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volume

457

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28 February 2020

page(s)

561-566

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issue

4

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Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease

28 February 2020

cites work

1 reference

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Saposin C protects glucocerebrosidase against α-synuclein inhibition.

13 July 2018

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Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution

13 July 2018

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Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation

13 July 2018

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Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity.

13 July 2018

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The role of saposin C in Gaucher disease

13 July 2018

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High-precision isothermal titration calorimetry with automated peak-shape analysis.

13 July 2018

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CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy

13 July 2018

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Exploring the link between glucocerebrosidase mutations and parkinsonism

13 July 2018

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

13 July 2018

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Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases

13 July 2018

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Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.

13 July 2018

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Tryptophan probes at the alpha-synuclein and membrane interface.

13 July 2018

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Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

13 July 2018

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Molecular imaging of membrane interfaces reveals mode of beta-glucosidase activation by saposin C.

13 July 2018

1 reference

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Inference of macromolecular assemblies from crystalline state

13 July 2018

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Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids

13 July 2018

1 reference

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Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles

13 July 2018

1 reference

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On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation

13 July 2018

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

13 July 2018

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Acid beta-glucosidase: intrinsic fluorescence and conformational changes induced by phospholipids and saposin C.

13 July 2018

1 reference

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Identification of the binding and activating sites of the sphingolipid activator protein, saposin C, with glucocerebrosidase

13 July 2018

1 reference

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In vitro detergent activation of lysosomal acid beta-glucosidase in the spleen of normal and type 1 Gaucher patients is not accompanied by change in aggregation state

13 July 2018

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Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase

13 July 2018

1 reference

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Direct Visualization of Saposin Remodelling of Lipid Bilayers

27 September 2018

1 reference

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Mutation in saposin D domain of sphingolipid activator protein gene causes urinary system defects and cerebellar Purkinje cell degeneration with accumulation of hydroxy fatty acid-containing ceramide in mouse

27 September 2018

1 reference

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Functional organization of saposin C. Definition of the neurotrophic and acid beta-glucosidase activation regions

15 November 2018

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12 December 2020

Penetrance of PD in Glucocerebrosidase Gene Mutation Carriers

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12 December 2020

Effect of saposins A and C on the enzymatic hydrolysis of liposomal glucosylceramide

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12 December 2020

Determination of the interface of a large protein complex by transferred cross-saturation measurements

1 reference

12 December 2020

10.1016/J.BBRC.2015.01.024

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DOI

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28 February 2020

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