A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder (Q35183619)

7 August 2017

title

A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder (English)

1 reference

7 August 2017

Ernesto Callegari

1

1 reference

7 August 2017

Bimal Malhotra

2

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7 August 2017

Peter J Bungay

3

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7 August 2017

Rob Webster

4

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7 August 2017

Katherine S Fenner

5

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7 August 2017

Sarah Kempshall

6

1 reference

7 August 2017

Jennifer L LaPerle

7

1 reference

7 August 2017

Martin C Michel

8

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7 August 2017

Gary G Kay

9

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7 August 2017

language of work or name

English

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publication date

1 August 2011

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British Journal of Clinical Pharmacology

7 August 2017

published in

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7 August 2017

volume

72

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7 August 2017

issue

2

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7 August 2017

page(s)

235-246

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Membrane transporters in drug development

7 August 2017

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13 July 2018

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13 July 2018

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Pathophysiology: the varieties of bladder overactivity

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Trospium chloride has no effect on memory testing and is assay undetectable in the central nervous system of older patients with overactive bladder

13 July 2018

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The role of p-glycoprotein in limiting brain penetration of the peripherally acting anticholinergic overactive bladder drug trospium chloride

27 September 2018

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27 September 2018

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27 September 2018

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In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment

27 September 2018

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27 September 2018

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Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder

27 September 2018

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Differential effects of the antimuscarinic agents darifenacin and oxybutynin ER on memory in older subjects

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162653

Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162653

Effects on sleep of anticholinergics used for overactive bladder treatment in healthy volunteers aged > or = 50 years

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162653

Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.

27 September 2018

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P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists

27 September 2018

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Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery

27 September 2018

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Efficacy, safety, and tolerability of extended-release once-daily tolterodine treatment for overactive bladder in older versus younger patients

27 September 2018

1 reference

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Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162653

Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

27 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162653

An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction

27 September 2018

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12 December 2020

Urinary incontinence in both sexes: prevalence rates and impact on quality of life and sexual life

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12 December 2020

Effects of scopolamine and nicotine on human rapid information processing performance

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12 December 2020

Direct measurement of muscarinic agents in the central nervous system of mice using ex vivo binding

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12 December 2020

Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome

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12 December 2020

Drug equilibration across the blood-brain barrier--pharmacokinetic considerations based on the microdialysis method

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12 December 2020

10.1111/J.1365-2125.2011.03961.X

Identifiers

DOI

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7 August 2017

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7 August 2017

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