Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival (Q35187029)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21821917%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival (English)

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9 February 2020

5

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9 February 2020

author name string

Tero-Pekka Alastalo

1

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9 February 2020

Molong Li

2

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9 February 2020

Vinicio de Jesus Perez

3

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9 February 2020

David Pham

4

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9 February 2020

Jordon K Wang

6

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9 February 2020

Minna Koskenvuo

7

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9 February 2020

Lingli Wang

8

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9 February 2020

Bruce A Freeman

9

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9 February 2020

Howard Y Chang

10

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9 February 2020

Marlene Rabinovitch

11

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9 February 2020

language of work or name

English

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publication date

8 August 2011

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Journal of Clinical Investigation

9 February 2020

published in

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9 February 2020

volume

121

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9 February 2020

issue

9

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9 February 2020

page(s)

3735-3746

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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

9 February 2020

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BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways

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Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.

13 July 2018

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Endogenous regulation of cardiovascular function by apelin-APJ.

13 July 2018

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S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4

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Emerging role of bone morphogenetic proteins in angiogenesis

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Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways.

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Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

13 July 2018

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Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension.

13 July 2018

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Molecular recognition of nitrated fatty acids by PPARγ

13 July 2018

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Retardation of retinal vascular development in apelin-deficient mice

13 July 2018

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An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension

13 July 2018

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Nitro-fatty acid formation and signaling

13 July 2018

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In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure

13 July 2018

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Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis

13 July 2018

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

13 July 2018

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Peroxisome proliferator-activated receptor-gamma antagonists exhibit potent antiproliferative effects versus many hematopoietic and epithelial cancer cell lines

13 July 2018

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Therapeutic potential of interfering with apelin signalling.

13 July 2018

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Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin

13 July 2018

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Apoptosis of pulmonary microvascular endothelial cells stimulates vascular smooth muscle cell growth

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia

13 July 2018

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Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Expression Is Decreased in Pulmonary Hypertension and Affects Endothelial Cell Growth

13 July 2018

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13 July 2018

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Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility

13 July 2018

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Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

13 July 2018

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13 July 2018

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Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene

13 July 2018

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Characterization of apelin, the ligand for the APJ receptor

13 July 2018

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Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

13 July 2018

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Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension.

13 July 2018

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27 September 2018

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Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension.

27 September 2018

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Apelin protects myocardial injury induced by isoproterenol in rats

27 September 2018

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Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells.

27 September 2018

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Signaling molecules in nonfamilial pulmonary hypertension

27 September 2018

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Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.

27 September 2018

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Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor

27 September 2018

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Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

27 September 2018

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Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells

27 September 2018

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12 December 2020

Apelin: A new plasma marker of cardiopulmonary disease

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12 December 2020

Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension

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12 December 2020

PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease

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12 December 2020

Identifiers

DOI

10.1172/JCI43382

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21821917%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21821917%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference