The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans (Q35187072)

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9 February 2020

title

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans (English)

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9 February 2020

2

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11

Peter K Gregersen

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9 February 2020

author name string

Laurence Menard

1

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9 February 2020

Isabelle Isnardi

3

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9 February 2020

Yen-Shing Ng

4

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9 February 2020

Greta Meyers

5

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9 February 2020

Christopher Massad

6

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9 February 2020

Christina Price

7

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9 February 2020

Clara Abraham

8

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9 February 2020

Roja Motaghedi

9

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Jane H Buckner

10

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9 February 2020

Eric Meffre

12

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9 February 2020

language of work or name

English

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publication date

1 August 2011

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Journal of Clinical Investigation

9 February 2020

published in

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volume

121

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issue

9

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9 February 2020

page(s)

3635-3644

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Inflammation-independent defective early B cell tolerance checkpoints in rheumatoid arthritis.

9 February 2020

cites work

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Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

13 July 2018

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IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus

13 July 2018

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Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population

13 July 2018

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13 July 2018

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Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling

13 July 2018

1 reference

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B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

13 July 2018

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Sites and stages of autoreactive B cell activation and regulation.

13 July 2018

1 reference

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CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance

13 July 2018

1 reference

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Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene

13 July 2018

1 reference

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Regulation of B cell tolerance by the lupus susceptibility gene Ly108.

13 July 2018

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A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

13 July 2018

1 reference

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A checkpoint for autoreactivity in human IgM+ memory B cell development

13 July 2018

1 reference

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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

13 July 2018

1 reference

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Impaired early B cell tolerance in patients with rheumatoid arthritis.

13 July 2018

1 reference

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Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

13 July 2018

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Defective B cell tolerance checkpoints in systemic lupus erythematosus

13 July 2018

1 reference

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Bruton's tyrosine kinase is essential for human B cell tolerance

13 July 2018

1 reference

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Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163953

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

13 July 2018

1 reference

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Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis

13 July 2018

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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

13 July 2018

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Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies

13 July 2018

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Predominant autoantibody production by early human B cell precursors

13 July 2018

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Estrogen up-regulates Bcl-2 and blocks tolerance induction of naive B cells

13 July 2018

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The PTPN22 R620W polymorphism is associated with severe bacterial infections after human leukocyte antigen geno-identical haematopoietic stem-cell transplantations

13 July 2018

1 reference

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Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese.

27 September 2018

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Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

27 September 2018

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Autoantibodies as predictors of disease

15 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21804190

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI45790

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21804190%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

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9 February 2020

PubMed publication ID

21804190

1 reference