Toxicogenomics: an opportunity to optimise drug development and safety evaluation (Q35194490)

7 August 2017

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title

Toxicogenomics: an opportunity to optimise drug development and safety evaluation (English)

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7 August 2017

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Jeffrey A Kramer

1

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PubMed ID

12904143

7 August 2017

Kyle L Kolaja

series ordinal

2

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PubMed ID

12904143

7 August 2017

language of work or name

English

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publication date

1 September 2002

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Expert Opinion on Drug Safety

7 August 2017

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7 August 2017

1

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7 August 2017

3

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7 August 2017

275-286

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Concordance of the toxicity of pharmaceuticals in humans and in animals

7 August 2017

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The Sequence of the Human Genome

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On the sequencing of the human genome

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Genome analysis with gene expression microarrays

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RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays

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Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles

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Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks

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Proteomics: applications in basic and applied biology

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Assessment of cisplatin-induced nephrotoxicity by microarray technology

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Genomic analysis of metastasis reveals an essential role for RhoC

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ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages

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Gene expression profiling of initiated epidermal cells with benign or malignant tumor fates

21 January 2018

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Analysis of cytochrome P450 and phase II conjugating enzyme expression in adult male rat hepatocytes

21 January 2018

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Temporal gene expression analysis of monolayer cultured rat hepatocytes

21 January 2018

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Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.

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Mechanistic data and risk assessment of selected toxic end points of the thyroid gland

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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

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The use of genomics technology to investigate gene expression changes in cultured human liver cells

21 January 2018

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Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells

21 January 2018

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The enigma of arsenic carcinogenesis: role of metabolism

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Arsenic: health effects, mechanisms of actions, and research issues

21 January 2018

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Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses.

21 January 2018

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Physiological function as regulation of large transcriptional programs: the cellular response to genotoxic stress

21 January 2018

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Effects of methapyrilene measured in mitochondria isolated from naive and methapyrilene-treated rat and mouse hepatocytes

21 January 2018

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Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive genes in mouse liver by serial analysis of gene expression

21 January 2018

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Development of a toxicological gene array and quantitative assessment of this technology

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Applications of gene arrays in environmental toxicology: fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene

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Gene expression profiling predicts clinical outcome of breast cancer

21 January 2018

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Identification of high risk breast-cancer patients by gene expression profiling

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Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

21 January 2018

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Advances in pharmacogenetics and pharmacogenomics

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An updated two-dimensional gel database of rat liver proteins useful in gene regulation and drug effect studies.

21 January 2018

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The impact of genomics-based technologies on drug safety evaluation

21 January 2018

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Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies

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Minimum information about a microarray experiment (MIAME)-toward standards for microarray data

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21 January 2018

Identifiers

DOI

10.1517/14740338.1.3.275

1 reference

7 August 2017

1 reference

PubMed ID

12904143