The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study (Q35200032)

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English	The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study	scientific article

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scholarly article

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Europe PubMed Central

7 August 2017

The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study (English)

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Europe PubMed Central

7 August 2017

alcohol dependence

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based on heuristic

inferred from title

Marilyn Huestis

8

object named as

Marilyn Huestis

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Europe PubMed Central

7 August 2017

object named as

Markus Heilig

12

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author name string

Laura E Kwako

1

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Europe PubMed Central

7 August 2017

Primavera A Spagnolo

2

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Europe PubMed Central

7 August 2017

Melanie L Schwandt

3

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Europe PubMed Central

7 August 2017

Annika Thorsell

4

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Europe PubMed Central

7 August 2017

David T George

5

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Europe PubMed Central

7 August 2017

Reza Momenan

6

1 reference

Europe PubMed Central

7 August 2017

Daniel E Rio

7

1 reference

Europe PubMed Central

7 August 2017

Sebastien Anizan

9

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Europe PubMed Central

7 August 2017

Marta Concheiro

10

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Europe PubMed Central

7 August 2017

Rajita Sinha

11

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7 August 2017

language of work or name

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publication date

13 March 2015

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7 August 2017

Neuropsychopharmacology

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Europe PubMed Central

7 August 2017

40

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Europe PubMed Central

7 August 2017

5

1 reference

Europe PubMed Central

7 August 2017

1053-1063

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Europe PubMed Central

7 August 2017

https://scigraph.springernature.com/pub.10.1038/npp.2014.306

0 references

Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes

1 reference

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28 July 2018

Gabapentin treatment for alcohol dependence: a randomized clinical trial

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367465

28 July 2018

The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research

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28 July 2018

Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367465

28 July 2018

In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist

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28 July 2018

Pharmacogenetic approaches to the treatment of alcohol addiction

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28 July 2018

Prazosin effects on stress- and cue-induced craving and stress response in alcohol-dependent individuals: preliminary findings

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Effects of adrenal sensitivity, stress- and cue-induced craving, and anxiety on subsequent alcohol relapse and treatment outcomes

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28 July 2018

Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder

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28 July 2018

Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?

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28 July 2018

Modeling stress and drug craving in the laboratory: implications for addiction treatment development

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28 July 2018

Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin

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28 July 2018

Neurokinin 1 receptor antagonism as a possible therapy for alcoholism

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28 July 2018

The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367465

28 July 2018

A key role for corticotropin-releasing factor in alcohol dependence

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367465

28 July 2018

Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure

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28 July 2018

Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats

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28 July 2018

Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat.

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28 July 2018

The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1 ,5-a]-pyrimidine: a corticotropin-releasing factor (hCRF1) antagonist

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28 July 2018

Exposure to negative emotional cues and alcohol cue reactivity with alcoholics: a preliminary investigation

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AFNI: software for analysis and visualization of functional magnetic resonance neuroimages

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The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting

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28 July 2018

Development and initial validation of a measure of drinking urges in abstinent alcoholics

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An improved diagnostic evaluation instrument for substance abuse patients. The Addiction Severity Index.

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28 July 2018

Understanding and preventing relapse

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28 July 2018

Role of corticotropin-releasing factor in the median raphe nucleus in yohimbine-induced reinstatement of alcohol seeking in rats

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26 September 2018

Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists.

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Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals

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A 6-week randomized, placebo-controlled trial of CP-316,311 (a selective CRH1 antagonist) in the treatment of major depression

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Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence.

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3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.

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Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats.

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The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol.

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10.1038/NPP.2014.306

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Europe PubMed Central

7 August 2017

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Europe PubMed Central

7 August 2017

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Europe PubMed Central

7 August 2017

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