Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome. (Q35202911)

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English	Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.	scientific article

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10444595%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome (English)

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11 December 2019

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Catherine A Collins

1

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11 December 2019

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C Guthrie

2

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11 December 2019

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1 August 1999

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11 December 2019

Genes & Development

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11 December 2019

13

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11 December 2019

15

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11 December 2019

1970-1982

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11 December 2019

The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

A detailed view of a ribosomal active site: the structure of the L11-RNA complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Crystal structure of a conserved ribosomal protein-RNA complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Conservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Terminal intron dinucleotide sequences do not distinguish between U2- and U12-dependent introns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Construction of an in vivo-regulated U6 snRNA transcription unit as a tool to study U6 function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Functional analysis of the U5 snRNA loop 1 in the second catalytic step of yeast pre-mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Classification of introns: U2-type or U12-type

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

The role of U5 snRNP in pre-mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Trans mRNA splicing in trypanosomes: cloning and analysis of a PRP8-homologous gene from Trypanosoma brucei provides evidence for a U5-analogous RNP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Site-specific crosslinks of yeast U6 snRNA to the pre-mRNA near the 5' splice site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Identification of proteins that interact with exon sequences, splice sites, and the branchpoint sequence during each stage of spliceosome assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Assembly of a ribonucleoprotein catalyst by tertiary structure capture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

The second catalytic step of pre-mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Dynamic association of proteins with the pre-mRNA branch region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

RNA splicing. Activity in the spliceosome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

The interaction between the first and last intron nucleotides in the second step of pre-mRNA splicing is independent of other conserved intron nucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Extraordinary sequence conservation of the PRP8 splicing factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Extensive interactions of PRP8 protein with the 5' and 3' splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Interactions between the terminal bases of mammalian introns are retained in inosine-containing pre-mRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

RNA-RNA interactions in the spliceosome: unraveling the ties that bind

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Role of the 3' splice site consensus sequence in mammalian pre-mRNA splicing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Intron sequences involved in lariat formation during pre-mRNA splicing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Effects on mRNA splicing of mutations in the 3' region of the Saccharomyces cerevisiae actin intron

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Optimal alignments in linear space

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Spliceosomal RNA U6 is remarkably conserved from yeast to mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Structural plasticity broadens the specificity of an engineered protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

The generality of self-splicing RNA: relationship to nuclear mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

On the origin of RNA splicing and introns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Self-splicing of group I introns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Multiple roles for U6 snRNA in the splicing pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Two domains of yeast U6 small nuclear RNA required for both steps of nuclear precursor messenger RNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

A U-rich tract enhances usage of an alternative 3′ splice site in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

A rapid method for localized mutagenesis of yeast genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

An essential splicing factor, SLU7, mediates 3' splice site choice in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

28 July 2018

Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

26 September 2018

Genetic interaction between U6 snRNA and the first intron nucleotide in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

26 September 2018

Highly diverged U4 and U6 small nuclear RNAs required for splicing rare AT-AC introns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

26 September 2018

Mutations in U6 snRNA that alter splice site specificity: implications for the active site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

26 September 2018

Interaction between the first and last nucleotides of pre-mRNA introns is a determinant of 3' splice site selection in S. cerevisiae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

26 September 2018

U4/U5/U6 snRNP recognizes the 5' splice site in the absence of U2 snRNP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

26 September 2018

Functional linkage between the active site of alpha-lytic protease and distant regions of structure: scanning alanine mutagenesis of a surface loop affects activity and substrate specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

26 September 2018

Specificity of ligand binding in a buried nonpolar cavity of T4 lysozyme: linkage of dynamics and structural plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

26 September 2018

A novel role for a U5 snRNP protein in 3' splice site selection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

26 September 2018

Metal ion catalysis during splicing of premessenger RNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=316919

8 December 2018

A mutant D-amino acid aminotransferase with broad substrate specificity: construction by replacement of the interdomain loop Pro119-Arg120-Pro121 by Gly-Gly-Gly

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The invariant U5 snRNA loop 1 sequence is dispensable for the first catalytic step of pre-mRNA splicing in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mRNA splicing efficiency in yeast and the contribution of nonconserved sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a yeast snRNP protein and detection of snRNP-snRNP interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in yeast U5 snRNA alter the specificity of 5' splice-site cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for an essential non-Watson–Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The U5 and U6 small nuclear RNAs as active site components of the spliceosome

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of U6 snRNA in 5' splice site selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/10444595

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1101/GAD.13.15.1970

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11 December 2019

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Europe PubMed Central

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11 December 2019

PubMed publication ID

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Europe PubMed Central

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11 December 2019

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