Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer (Q35207110)

7 August 2017

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15 February 2023

Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer (English)

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G1 phase cell cycle checkpoints

7 August 2017

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20 August 2019

1 reference

17 November 2019

1 reference

15 February 2023

1 reference

26 August 2020

neoplastic gene expression regulation

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4 November 2020

1 reference

25 January 2021

cell population proliferation

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18 July 2021

1 reference

Chih-Pin Chuu

1

1 reference

7 August 2017

John M Kokontis

2

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7 August 2017

Richard A Hiipakka

3

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7 August 2017

Junichi Fukuchi

4

1 reference

7 August 2017

Hui-Ping Lin

5

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7 August 2017

Ching-Yu Lin

6

1 reference

7 August 2017

Chiech Huo

7

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7 August 2017

Liang-Cheng Su

8

1 reference

7 August 2017

23 August 2011

12 references

Journal of Biomedical Science

7 August 2017

3 April 2019

20 August 2019

8 September 2019

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21 December 2019

26 August 2020

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18 July 2021

15 February 2023

12 references

7 August 2017

3 April 2019

20 August 2019

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17 November 2019

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25 January 2021

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15 February 2023

18

1 reference

7 August 2017

63

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Creative Commons Attribution 2.0 Generic

7 August 2017

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https://scigraph.springernature.com/pub.10.1186/1423-0127-18-63

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cites work

Androgen suppresses proliferation of castration-resistant LNCaP 104-R2 prostate cancer cells through androgen receptor, Skp2, and c-Myc

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13 July 2018

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Pathogenesis of osteoblastic bone metastases from prostate cancer

13 July 2018

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Diabetes and cardiovascular disease during androgen deprivation therapy: observational study of veterans with prostate cancer

13 July 2018

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Interleukin-6 regulates androgen synthesis in prostate cancer cells

13 July 2018

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Phase 1 trial of high-dose exogenous testosterone in patients with castration-resistant metastatic prostate cancer

13 July 2018

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A randomized phase 1 study of testosterone replacement for patients with low-risk castration-resistant prostate cancer

13 July 2018

1 reference

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Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells

13 July 2018

1 reference

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Shifting the paradigm of testosterone and prostate cancer: the saturation model and the limits of androgen-dependent growth

13 July 2018

1 reference

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American Society of Clinical Oncology endorsement of the Cancer Care Ontario Practice Guideline on nonhormonal therapy for men with metastatic hormone-refractory (castration-resistant) prostate cancer

13 July 2018

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Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis

13 July 2018

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The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells

13 July 2018

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Modulation of liver X receptor signaling as novel therapy for prostate cancer

13 July 2018

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Prevalence of prostate cancer among hypogonadal men with prostate-specific antigen levels of 4.0 ng/mL or less

13 July 2018

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Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist

13 July 2018

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Role of androgen receptor in the progression of human prostate tumor cells to androgen independence and insensitivity

13 July 2018

1 reference

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Androgen causes growth suppression and reversion of androgen-independent prostate cancer xenografts to an androgen-stimulated phenotype in athymic mice

13 July 2018

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Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells

13 July 2018

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Molecular characterization of an improved vector for evaluation of the tumor suppressor versus oncogene abilities of the androgen receptor

13 July 2018

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A re-assessment of the role of combined androgen blockade for advanced prostate cancer

13 July 2018

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13 July 2018

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The androgen axis in recurrent prostate cancer

13 July 2018

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Molecular determinants of resistance to antiandrogen therapy

13 July 2018

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Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance

13 July 2018

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Androgen Receptor Gene Amplification and Protein Expression in Recurrent Prostate Cancer

13 July 2018

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Enhanced androgen receptor signaling correlates with the androgen-refractory growth in a newly established MDA PCa 2b-hr human prostate cancer cell subline

13 July 2018

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13 July 2018

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The influence of finasteride on the development of prostate cancer

13 July 2018

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13 July 2018

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The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells

13 July 2018

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13 July 2018

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13 July 2018

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Androgen receptor expression and cellular proliferation during transition from androgen-dependent to recurrent growth after castration in the CWR22 prostate cancer xenograft

13 July 2018

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Overexpressed androgen receptor linked to p21WAF1 silencing may be responsible for androgen independence and resistance to apoptosis of a prostate cancer cell line.

13 July 2018

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Androgen receptor mediates the reduced tumor growth, enhanced androgen responsiveness, and selected target gene transactivation in a human prostate cancer cell line.

13 July 2018

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Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer

13 July 2018

1 reference

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Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen.

13 July 2018

1 reference

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Inhibition of growth and induction of apoptosis by androgens of a variant of LNCaP cell line

13 July 2018

1 reference

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Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients

13 July 2018

1 reference

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

13 July 2018

1 reference

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Molecular action of androgen in the normal and neoplastic prostate

13 July 2018

1 reference

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Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Human androgen receptor expression in prostate cancer following androgen ablation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Androgen-repressed phenotype in human prostate cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Human prostate tumor growth in athymic mice: inhibition by androgens and stimulation by finasteride

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Variants of the human prostate LNCaP cell line as tools to study discrete components of the androgen-mediated proliferative response

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

In vivo amplification of the androgen receptor gene and progression of human prostate cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Androgens inhibit the proliferation of a variant of the human prostate cancer cell line LNCaP.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Selective Retention of Dihydrotestosterone by Prostatic Nuclei

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Inhibition of steroid 5α-reductase by specific aliphatic unsaturated fatty acids

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Modulation of liver X receptor signaling as a prevention and therapy for colon cancer.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Re: Russell Szmulewitz, Supriya Mohile, Edwin Posadas, et al. A randomized phase 1 study of testosterone replacement for patients with low-risk castration-resistant prostate cancer. Eur Urol 2009;56:97-104.

26 September 2018

1 reference

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Low testosterone and risk of biochemical recurrence and poorly differentiated prostate cancer at radical prostatectomy

26 September 2018

1 reference

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Intermittent androgen blockade should be regarded as standard therapy in prostate cancer.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Prolonged control of progressive castration-resistant metastatic prostate cancer with testosterone replacement therapy: the case for a prospective trial

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Androgen deprivation therapy increases cardiovascular morbidity in men with prostate cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Molecular alterations associated with LNCaP cell progression to androgen independence

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Interrogating androgen receptor function in recurrent prostate cancer.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Recovery of serum testosterone, LH and FSH levels following neoadjuvant hormone cytoreduction and radical radiotherapy in localized prostate cancer

26 September 2018

1 reference

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Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system

26 September 2018

1 reference

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Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170584

Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer

26 September 2018

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Intermittent androgen suppression for prostate cancer: Canadian Prospective Trial and related observations

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12 December 2020

Sampling strategy for prostate tissue microarrays for Ki-67 and androgen receptor biomarkers

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12 December 2020

The LNCaP cell line--a new model for studies on human prostatic carcinoma

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12 December 2020

Effects of intermittent androgen suppression on androgen-dependent tumors. Apoptosis and serum prostate-specific antigen

1 reference

12 December 2020

A controlled trial of bicalutamide versus castration in patients with advanced prostate cancer

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12 December 2020

Intermittent androgen suppression delays progression to androgen-independent regulation of prostate-specific antigen gene in the LNCaP prostate tumour model

1 reference

12 December 2020

Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor

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12 December 2020

Prospective determination of the hormonal response after cessation of luteinizing hormone-releasing hormone agonist treatment in patients with prostate cancer

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Identifiers

DOI

10.1186/1423-0127-18-63

1 reference

Dimensions Publication ID

7 August 2017

0 references

1 reference

7 August 2017

1 reference