The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms. (Q35207740)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9716405%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

title

The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms (English)

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3 December 2019

1

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3 December 2019

Simon Brackenridge

3

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3 December 2019

author name string

Y Takagaki

2

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3 December 2019

M Wollerton

4

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3 December 2019

J L Manley

5

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3 December 2019

N J Proudfoot

6

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3 December 2019

publication date

1 August 1998

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3 December 2019

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3 December 2019

volume

12

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3 December 2019

issue

16

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3 December 2019

page(s)

2522-2534

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U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase.

3 December 2019

cites work

1 reference

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Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits

13 July 2018

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Mechanism and regulation of mRNA polyadenylation

13 July 2018

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The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins

13 July 2018

1 reference

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Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo

13 July 2018

1 reference

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RNA recognition by the human polyadenylation factor CstF

13 July 2018

1 reference

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Transcription and polyadenylation in a short human intergenic region.

13 July 2018

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3'-end-forming signals of yeast mRNA.

13 July 2018

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The end of the message--another link between yeast and mammals.

13 July 2018

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Ending the message is not so simple

13 July 2018

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13 July 2018

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Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors

13 July 2018

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An intron enhancer recognized by splicing factors activates polyadenylation

13 July 2018

1 reference

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Direct evidence that polypyrimidine tract binding protein (PTB) is essential for internal initiation of translation of encephalomyocarditis virus RNA

13 July 2018

1 reference

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Assembly of a processive messenger RNA polyadenylation complex

13 July 2018

1 reference

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Upstream and downstream cis-acting elements for cleavage at the L4 polyadenylation site of adenovirus-2.

13 July 2018

1 reference

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Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon.

13 July 2018

1 reference

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Sequences homologous to 5' splice sites are required for the inhibitory activity of papillomavirus late 3' untranslated regions

13 July 2018

1 reference

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A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein

13 July 2018

1 reference

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Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

The 64-kilodalton subunit of the CstF polyadenylation factor binds to pre-mRNAs downstream of the cleavage site and influences cleavage site location

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins

13 July 2018

1 reference

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Upstream sequence elements enhance poly(A) site efficiency of the C2 complement gene and are phylogenetically conserved.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Regulation of alternative 3' splice site selection by constitutive splicing factors.

13 July 2018

1 reference

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

13 July 2018

1 reference

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Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements

13 July 2018

1 reference

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Two proteins crosslinked to RNA containing the adenovirus L3 poly(A) site require the AAUAAA sequence for binding

13 July 2018

1 reference

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Sequences capable of restoring poly(A) site function define two distinct downstream elements.

13 July 2018

1 reference

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The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3' termini

13 July 2018

1 reference

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A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif

13 July 2018

1 reference

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Sequences upstream of AAUAAA influence poly(A) site selection in a complex transcription unit

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Efficiency of utilization of the simian virus 40 late polyadenylation site: effects of upstream sequences

13 July 2018

1 reference

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Four factors are required for 3'-end cleavage of pre-mRNAs

13 July 2018

1 reference

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Multiple forms of poly(A) polymerases purified from HeLa cells function in specific mRNA 3'-end formation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Molecular analyses of two poly(A) site-processing factors that determine the recognition and efficiency of cleavage of the pre-mRNA.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Involvement of long terminal repeat U3 sequences overlapping the transcription control region in human immunodeficiency virus type 1 mRNA 3' end formation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

How the messenger got its tail: addition of poly(A) in the nucleus

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Purification of the cleavage and polyadenylation factor involved in the 3'-processing of messenger RNA precursors.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Characterization of cDNAs encoding the polypyrimidine tract-binding protein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Site-directed ribose methylation identifies 2'-OH groups in polyadenylation substrates critical for AAUAAA recognition and poly(A) addition

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Isolation and expression of cDNA clones encoding mammalian poly(A) polymerase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Cleavage and polyadenylation factor CPF specifically interacts with the pre-mRNA 3' processing signal AAUAAA

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Transcriptional termination between the closely linked human complement genes C2 and factor B: common termination factor for C2 and c-myc?

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Regulation of polyadenylation in hepatitis B viruses: stimulation by the upstream activating signal PS1 is orientation-dependent, distance-independent, and additive

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

A uridylate tract mediates efficient heterogeneous nuclear ribonucleoprotein C protein-RNA cross-linking and functionally substitutes for the downstream element of the polyadenylation signal

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Poly(A) site efficiency reflects the stability of complex formation involving the downstream element

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Varied poly(A) site efficiency in the adenovirus major late transcription unit

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Activation of HIV-1 pre-mRNA 3' processing in vitro requires both an upstream element and TAR.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Regulation of polyadenylation in human immunodeficiency virus (HIV): contributions of promoter proximity and upstream sequences

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Separation of factors required for cleavage and polyadenylation of yeast pre-mRNA

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

3' non-coding region sequences in eukaryotic messenger RNA

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Purification with monoclonal antibody of a predominant leukocyte-common antigen and glycoprotein from rat thymocytes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

The HIV-1 5' LTR poly(A) site is inactivated by U1 snRNP interaction with the downstream major splice donor site.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Sequence elements upstream of the 3' cleavage site confer substrate strength to the adenovirus L1 and L3 polyadenylation sites

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317083

RNA14 and RNA15 proteins as components of a yeast pre-mRNA 3'-end processing factor

26 September 2018

1 reference

12 December 2020

CPSF recognition of an HIV-1 mRNA 3'-processing enhancer: multiple sequence contacts involved in poly(A) site definition

1 reference

12 December 2020

Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site

1 reference

12 December 2020

A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs

1 reference

12 December 2020

Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro

1 reference

12 December 2020

Position-dependent sequence elements downstream of AAUAAA are required for efficient rabbit beta-globin mRNA 3' end formation

1 reference

12 December 2020

Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation

1 reference

12 December 2020

Primary structure and expression of bovine poly(A) polymerase

1 reference

12 December 2020

Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus

1 reference

12 December 2020

Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal

1 reference

12 December 2020

Requirement of a downstream sequence for generation of a poly(A) addition site

1 reference

12 December 2020

A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.12.16.2522

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9716405%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9716405%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

1 reference