Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair (Q35213276)

7 August 2017

1 reference

title

Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair (English)

1 reference

7 August 2017

Xiaoping Wu

1

1 reference

7 August 2017

Junli Feng

2

1 reference

7 August 2017

Atsumasa Komori

3

1 reference

7 August 2017

Edmund C Kim

4

1 reference

7 August 2017

Hong Zan

5

1 reference

7 August 2017

Paolo Casali

6

1 reference

7 August 2017

1 July 2003

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Journal of Clinical Immunology

7 August 2017

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7 August 2017

23

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7 August 2017

235-246

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7 August 2017

4

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https://scigraph.springernature.com/pub.10.1023/a:1024571714867

7 August 2017

0 references

cites work

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Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements

28 July 2018

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

28 July 2018

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De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

28 July 2018

1 reference

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Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

28 July 2018

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

28 July 2018

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

28 July 2018

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AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line

28 July 2018

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Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.

28 July 2018

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

28 July 2018

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Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity

28 July 2018

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Somatic immunoglobulin hypermutation

28 July 2018

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Error rate and specificity of human and murine DNA polymerase eta

28 July 2018

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DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

28 July 2018

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The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

28 July 2018

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28 July 2018

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Transcription, beta-like DNA polymerases and hypermutation

28 July 2018

1 reference

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DNA polymerase iota and related rad30-like enzymes

28 July 2018

1 reference

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Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p

28 July 2018

1 reference

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Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

28 July 2018

1 reference

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

28 July 2018

1 reference

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Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

28 July 2018

1 reference

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Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells.

28 July 2018

1 reference

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Specificity of DNA lesion bypass by the yeast DNA polymerase eta.

28 July 2018

1 reference

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Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu-->S gamma, S gamma-->S alpha DNA recombination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Evolution of somatic hypermutation and gene conversion in adaptive immunity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

A role for REV3 in mutagenesis during double-strand break repair in Saccharomyces cerevisiae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

In vitro triggering of somatic mutation in human naive B cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Induction of somatic mutation in a human B cell line in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Analysis of somatic mutation in five B cell subsets of human tonsil

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

IL-4 plus CD40 monoclonal antibody induces human B cells gamma subclass-specific isotype switch: switching to gamma 1, gamma 3, and gamma 4, but not gamma 2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

DNA polymerase kappa deficiency does not affect somatic hypermutation in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Mice deficient for the type II topoisomerase-like DNA transesterase Spo11 show normal immunoglobulin somatic hypermutation and class switching

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Low fidelity DNA synthesis by human DNA polymerase-eta.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

The evolutionarily conserved sequence upstream of the human Ig heavy chain S gamma 3 region is an inducible promoter: synergistic activation by CD40 ligand and IL-4 via cooperative NF-kappa B and STAT-6 binding sites.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Somatic hypermutation in the heavy chain locus correlates with transcription.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Receptor editing and commitment in B lymphocytes.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

CD40 ligand and appropriate cytokines induce switching to IgG, IgA, and IgE and coordinated germinal center and plasmacytoid phenotypic differentiation in a human monoclonal IgM+IgD+ B cell line.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

The regulation of self-reactive B cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624321

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

26 September 2018

1 reference

12 December 2020

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

12 December 2020

The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line

1 reference

12 December 2020

Origin of Antibody Variation

1 reference

12 December 2020

Codon bias targets mutation.

1 reference

12 December 2020

B Cell Receptor Engagement and T Cell Contact Induce bcl-6 Somatic Hypermutation in Human B Cells: Identity with Ig Hypermutation

1 reference

12 December 2020

Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase

1 reference

12 December 2020

Ig gene somatic hypermutation in mice defective for DNA polymerase delta proofreading

1 reference

12 December 2020

Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation

1 reference

12 December 2020

Somatic hypermutation of VkappaJkappa rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs

1 reference

12 December 2020

Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation

1 reference

12 December 2020

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

1 reference

12 December 2020

Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain

1 reference

12 December 2020

Probing immunoglobulin gene hypermutation with microsatellites suggests a nonreplicative short patch DNA synthesis process

1 reference

12 December 2020

Recombination-based mechanisms for somatic hypermutation

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1024571714867

1 reference

Dimensions Publication ID

7 August 2017

0 references

1 reference

7 August 2017

1 reference