CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. (Q35213298)

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English	CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.	scientific article

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8 February 2020

CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease (English)

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8 February 2020

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Alzheimer's disease

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8 February 2020

Tiina M. Kauppinen

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8 February 2020

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8 February 2020

Richard M Ransohoff

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Richard M Ransohoff

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8 February 2020

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Seo-Hyun Cho

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8 February 2020

Yungui Zhou

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8 February 2020

Brian Halabisky

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8 February 2020

Li Gan

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19 July 2011

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8 February 2020

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Journal of Biological Chemistry

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8 February 2020

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8 February 2020

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8 February 2020

32713-32722

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

1 reference

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13 July 2018

CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis

1 reference

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13 July 2018

The myeloid cells of the central nervous system parenchyma

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13 July 2018

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network

1 reference

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13 July 2018

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

1 reference

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13 July 2018

CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.

1 reference

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13 July 2018

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13 July 2018

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13 July 2018

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

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13 July 2018

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13 July 2018

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13 July 2018

Heterogeneity of microglial activation in the innate immune response in the brain

1 reference

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13 July 2018

The liberation of fractalkine in the dorsal horn requires microglial cathepsin S.

1 reference

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13 July 2018

Microglial physiology: unique stimuli, specialized responses

1 reference

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13 July 2018

Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice

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13 July 2018

Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues

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13 July 2018

Recognition memory and the medial temporal lobe: a new perspective

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13 July 2018

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

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13 July 2018

Control of microglial neurotoxicity by the fractalkine receptor

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13 July 2018

Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice.

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13 July 2018

Microglia as a potential bridge between the amyloid beta-peptide and tau.

1 reference

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13 July 2018

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

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13 July 2018

Inflammation in neurodegenerative disease--a double-edged sword

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13 July 2018

Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine

1 reference

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13 July 2018

Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)

1 reference

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13 July 2018

Recognition memory: what are the roles of the perirhinal cortex and hippocampus?

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13 July 2018

Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival

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13 July 2018

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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13 July 2018

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

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Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

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Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1

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Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

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Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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Inflammation and Alzheimer's disease pathogenesis

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers.

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26 September 2018

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

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26 September 2018

Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity

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Interleukin-6: a cytokine to forget

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26 September 2018

Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway.

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26 September 2018

Production and neuroprotective functions of fractalkine in the central nervous system

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Immunocytochemical evidence that amyloid beta (1-42) impairs endogenous antioxidant systems in vivo

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26 September 2018

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10.1074/JBC.M111.254268

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8 February 2020

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8 February 2020

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8 February 2020

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