Vascular endothelial growth factor receptor-2: its unique signaling and specific ligand, VEGF-E. (Q35216291)

7 August 2017

1 reference

title

Vascular endothelial growth factor receptor-2: its unique signaling and specific ligand, VEGF-E. (English)

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vascular endothelial growth factor receptor-2 signaling pathway

7 August 2017

0 references

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Gene Ontology release 2020-05-02

Masabumi Shibuya

1

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PubMed ID

12967471

7 August 2017

language of work or name

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1 September 2003

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7 August 2017

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7 August 2017

94

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7 August 2017

751-756

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7 August 2017

9

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Mechanisms of angiogenesis

7 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

The biology of vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Guidance of cell migration by the Drosophila PDGF/VEGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Vascular endothelial growth factor receptor family genes: when did the three genes phylogenetically segregate?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

A set of loop-1 and -3 structures in the novel vascular endothelial growth factor (VEGF) family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Mapping of the Sites Involved in Ligand Association and Dissociation at the Extracellular Domain of the Kinase Insert Domain-containing Receptor for Vascular Endothelial Growth Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Vascular Endothelial Growth Factor Induction of the Angiogenic Phenotype Requires Ras Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2003.TB01514.X

10.1111/J.1349-7006.2003.TB01514.X

21 January 2018

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12967471