Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans (Q35220386)

7 August 2017

title

Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans (English)

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7 August 2017

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Henry S Friedman

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Darell D Bigner

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Annick Desjardins

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Allan H Friedman

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David A Reardon

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Roger E McLendon

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James J Vredenburgh

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James E Herndon

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Robert J Schmittling

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Kendra L Congdon

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Duane A Mitchell

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7 August 2017

Xiuyu Cui

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7 August 2017

Luis Sanchez-Perez

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7 August 2017

David J Snyder

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Gary E Archer

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John H Sampson

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language of work or name

English

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publication date

18 July 2011

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7 August 2017

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7 August 2017

volume

118

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7 August 2017

issue

11

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7 August 2017

page(s)

3003-3012

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CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis

7 August 2017

cites work

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Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

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Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines.

13 July 2018

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Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma

13 July 2018

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Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?

13 July 2018

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Systemic anti-CD25 monoclonal antibody administration safely enhances immunity in murine glioma without eliminating regulatory T cells

13 July 2018

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Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.

13 July 2018

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

13 July 2018

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Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

13 July 2018

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Cancer immunotherapy: moving beyond current vaccines

13 July 2018

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Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta

13 July 2018

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Selective CD4+ lymphopenia in melanoma patients treated with temozolomide: a toxicity with therapeutic implications

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175779

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175779

T cell homeostatic proliferation elicits effective antitumor autoimmunity

13 July 2018

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The IL-2/IL-15 receptor systems: targets for immunotherapy

13 July 2018

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Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery

13 July 2018

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Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Regulatory CD4+CD25+Foxp3+ T cells selectively inhibit the spontaneous form of lymphopenia-induced proliferation of naive T cells.

13 July 2018

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Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it.

26 September 2018

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Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175779

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer.

26 September 2018

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How lymphotoxic is dose-intensified temozolomide? The glioblastoma experience

26 September 2018

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Temozolomide for melanoma: new toxicities and new opportunities

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175779

Human cytomegalovirus infection and expression in human malignant glioma.

26 September 2018

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Response criteria for phase II studies of supratentorial malignant glioma

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175779

Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients

26 September 2018

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12 December 2020

H-2Kb transfection of B16 melanoma cells results in reduced tumourigenicity and metastatic competence

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12 December 2020

Cutting Edge: Anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells

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12 December 2020

Selective lymphopenia and opportunistic infections in neuroendocrine tumor patients receiving temozolomide

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12 December 2020

10.1182/BLOOD-2011-02-334565

Identifiers

DOI

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7 August 2017

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7 August 2017

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