The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility (Q35228445)

7 August 2017

title

The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility (English)

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27

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Marisa L Martin-Fernandez

7 August 2017

Daniel J Rolfe

10

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Marisa L Martin-Fernandez

28

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Gilbert Fruhwirth

Gilbert Fruhwirth

19

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Dimitra Dafou

Dimitra Dafou

12

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Simon Ameer-beg

Simon M Ameer-Beg

31

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Andreas Plückthun

Andreas Plückthun

Peter Joseph Jacques Parker

22

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Peter Parker

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Tony Ng

Tony Ng

32

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Michael Simpson

Michael A Simpson

13

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Sarah E. Pinder

15

Sarah Pinder

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Tai Kiuchi

1

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Elena Ortiz-Zapater

2

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James Monypenny

3

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Daniel R Matthews

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Jody Barbeau

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Oana Coban

7

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Katherine Lawler

8

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Brian Burford

9

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Emanuele de Rinaldis

11

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Natalie Woodman

14

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Cheryl E Gillett

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Viviane Devauges

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Simon P Poland

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Pierfrancesco Marra

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Ykelien L Boersma

21

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William J Gullick

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Yosef Yarden

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George Santis

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Martyn Winn

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Andrew Tutt

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7 August 2017

publication date

19 August 2014

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7 August 2017

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7 August 2017

volume

7

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7 August 2017

issue

339

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7 August 2017

page(s)

ra78

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EGF-ERBB signalling: towards the systems level

7 August 2017

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Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2

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The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells

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Specificity within the EGF family/ErbB receptor family signaling network

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Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation

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Clathrin-independent endocytosis of ubiquitinated cargos

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Threshold-controlled ubiquitination of the EGFR directs receptor fate

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

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Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer

21 January 2018

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Molecular portraits of human breast tumours

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Role of ErbB4 in breast cancer

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Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase

21 January 2018

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A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis

21 January 2018

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The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation

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Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.

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Role of epidermal growth factor receptor degradation in gemcitabine-mediated cytotoxicity.

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Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells

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Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells.

21 January 2018

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Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility

21 January 2018

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A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility

21 January 2018

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Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility

21 January 2018

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Imaging protein kinase Calpha activation in cells

21 January 2018

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Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.

21 January 2018

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Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells

21 January 2018

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Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42

21 January 2018

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An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Kinase-mediated quasi-dimers of EGFR

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Heparin-binding EGF-like growth factor: a juxtacrine growth factor

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

21 January 2018

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Efficient selection of DARPins with sub-nanomolar affinities using SRP phage display

21 January 2018

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Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.

21 January 2018

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Integrating conflicting chemotactic signals. The role of memory in leukocyte navigation

21 January 2018

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

21 January 2018

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Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

ErbB receptors: from oncogenes to targeted cancer therapies

21 January 2018

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ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding

21 January 2018

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ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

21 January 2018

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Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

21 January 2018

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Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer

21 January 2018

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Integrating receptor signal inputs that influence small Rho GTPase activation dynamics at the immunological synapse

21 January 2018

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ErbB2 Is Necessary for ErbB4 Ligands to Stimulate Oncogenic Activities in Models of Human Breast Cancer

21 January 2018

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Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth

21 January 2018

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Computational modeling of the EGF-receptor system: a paradigm for systems biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Computational modelling of ErbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Systems analysis of EGF receptor signaling dynamics with microwestern arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Crosstalk in Met receptor oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Type 1 growth factor receptor expression in node positive breast cancer: adverse prognostic significance of c-erbB-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Epidermal growth factor receptor distribution during chemotactic responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Intracellular coupling of adhesion receptors: molecular proximity measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Automated multidimensional single molecule fluorescence microscopy feature detection and tracking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Single-molecule imaging and fluorescence lifetime imaging microscopy show different structures for high- and low-affinity epidermal growth factor receptors in A431 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Single-molecule enzymatic dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Imaging proteins in vivo using fluorescence lifetime microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Are growth factors chemotactic agents?

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

FIRMA: a method for detection of alternative splicing from exon array data

21 January 2018

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Features and development of Coot

21 January 2018

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VMD: visual molecular dynamics

21 January 2018

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Presenting your structures: the CCP4mg molecular-graphics software

21 January 2018

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EGF receptor trafficking: consequences for signaling and cancer

21 January 2018

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A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005157

Multiphoton time-domain fluorescence lifetime imaging microscopy: practical application to protein-protein interactions using global analysis

21 January 2018

1 reference

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10.1126/SCISIGNAL.2005157

21 January 2018

Identifiers

DOI

1 reference

7 August 2017

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