How does genome instability affect lifespan?: roles of rDNA and telomeres (Q35228479)

7 August 2017

5 references

20 June 2019

30 June 2019

2 August 2019

14 September 2019

12 October 2019

How does genome instability affect lifespan?: roles of rDNA and telomeres (English)

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7 August 2017

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2 August 2019

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14 September 2019

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12 October 2019

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Takehiko Kobayashi

1

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7 August 2017

publication date

1 June 2011

6 references

7 August 2017

20 June 2019

30 June 2019

2 August 2019

14 September 2019

12 October 2019

6 references

7 August 2017

20 June 2019

30 June 2019

2 August 2019

14 September 2019

12 October 2019

16

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7 August 2017

issue

6

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7 August 2017

page(s)

617-624

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Creative Commons Attribution 2.5 Generic

7 August 2017

copyright license

5 references

20 June 2019

30 June 2019

2 August 2019

14 September 2019

Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast

12 October 2019

cites work

1 reference

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Annotating non-coding regions of the genome

13 July 2018

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Telomerase reverse transcriptase delays aging in cancer-resistant mice

13 July 2018

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Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

13 July 2018

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The longest telomeres: a general signature of adult stem cell compartments

13 July 2018

1 reference

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Immortal strands? Give me a break

13 July 2018

1 reference

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The immortal strand hypothesis: segregation and reconstruction.

13 July 2018

1 reference

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Abnormality in initiation program of DNA replication is monitored by the highly repetitive rRNA gene array on chromosome XII in budding yeast

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Strategies to maintain the stability of the ribosomal RNA gene repeats--collaboration of recombination, cohesion, and condensation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Telomerase regulation and stem cell behaviour

13 July 2018

1 reference

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Identifying gene-independent noncoding functional elements in the yeast ribosomal DNA by phylogenetic footprinting.

13 July 2018

1 reference

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Overview of caloric restriction and ageing

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

A DNA damage checkpoint response in telomere-initiated senescence

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

DNA damage foci at dysfunctional telomeres

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Transcription-dependent recombination and the role of fork collision in yeast rDNA.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

The economics of ribosome biosynthesis in yeast

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Elimination of replication block protein Fob1 extends the life span of yeast mother cells.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Extension of life-span by introduction of telomerase into normal human cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Extrachromosomal rDNA circles--a cause of aging in yeast

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Positional cloning of the Werner's syndrome gene

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

The Bloom's syndrome gene product is homologous to RecQ helicases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Telomeres shorten during ageing of human fibroblasts

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Mutation selection and the natural history of cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

Abundance of ribosomal RNA gene copies maintains genome integrity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3178783

A role for both RB and p53 in the regulation of human cellular senescence

26 September 2018

1 reference

12 December 2020

A new role of the rDNA and nucleolus in the nucleus--rDNA instability maintains genome integrity

1 reference

12 December 2020

The effect of replication initiation on gene amplification in the rDNA and its relationship to aging

1 reference

12 December 2020

An Age-Induced Switch to a Hyper-Recombinational State

1 reference

12 December 2020

10.1111/J.1365-2443.2011.01519.X

Identifiers

DOI

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7 August 2017

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7 August 2017

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