Combinatorial one-pot chemoenzymatic synthesis of heparin (Q35232430)

7 August 2017

title

Combinatorial one-pot chemoenzymatic synthesis of heparin (English)

1 reference

7 August 2017

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7

Robert J Linhardt

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7 August 2017

6

Jonathan S Dordick

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7 August 2017

Ujjwal Bhaskar

1

1 reference

7 August 2017

Guoyun Li

2

1 reference

7 August 2017

Li Fu

3

1 reference

7 August 2017

Akihiro Onishi

4

1 reference

7 August 2017

Mathew Suflita

5

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7 August 2017

publication date

7 November 2014

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7 August 2017

published in

Carbohydrate Polymers

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7 August 2017

volume

122

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7 August 2017

page(s)

399-407

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Synthetic oligosaccharides as active pharmaceutical ingredients: lessons learned from the full synthesis of one heparin derivative on a large scale

7 August 2017

cites work

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Structure and activity of a new low-molecular-weight heparin produced by enzymatic ultrafiltration

13 July 2018

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13 July 2018

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13 July 2018

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Effect of eliminase gene (elmA) deletion on heparosan production and shedding in Escherichia coli K5.

13 July 2018

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Structural characterization of pharmaceutical heparins prepared from different animal tissues

13 July 2018

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Chemoenzymatic synthesis of glycosaminoglycans: re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains

13 July 2018

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High cell density cultivation of a recombinant E. coli strain expressing a key enzyme in bioengineered heparin production

13 July 2018

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Uncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesis

13 July 2018

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Disaccharide analysis of glycosaminoglycan mixtures by ultra-high-performance liquid chromatography-mass spectrometry

13 July 2018

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Engineering of routes to heparin and related polysaccharides

13 July 2018

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Chemoenzymatic synthesis of homogeneous ultralow molecular weight heparins

13 July 2018

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Structural characterization of heparins from different commercial sources

13 July 2018

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Controlled Photochemical Depolymerization of K5 Heparosan, a Bioengineered Heparin Precursor

13 July 2018

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Control of the heparosan N-deacetylation leads to an improved bioengineered heparin

13 July 2018

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Preactivation-based, one-pot combinatorial synthesis of heparin-like hexasaccharides for the analysis of heparin-protein interactions.

13 July 2018

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Lessons learned from the contamination of heparin

13 July 2018

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Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis

13 July 2018

1 reference

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Solution structures of chemoenzymatically synthesized heparin and its precursors.

13 July 2018

1 reference

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Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events

13 July 2018

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Using an enzymatic combinatorial approach to identify anticoagulant heparan sulfate structures

13 July 2018

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Preparation and use of microarrays containing synthetic heparin oligosaccharides for the rapid analysis of heparin-protein interactions.

13 July 2018

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The role of heparan sulphate in inflammation

13 July 2018

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Enzymatic redesigning of biologically active heparan sulfate

13 July 2018

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Carbohydrate microarrays - a new set of technologies at the frontiers of glycomics

13 July 2018

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Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4379424

Heparin-protein interactions

13 July 2018

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Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins

13 July 2018

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Expression in Escherichia coli, purification and kinetic characterization of human heparan sulfate 3-O-sulfotransferase-1.

13 July 2018

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Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo

13 July 2018

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6-O-sulfotransferase-1 represents a critical enzyme in the anticoagulant heparan sulfate biosynthetic pathway

13 July 2018

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Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides.

13 July 2018

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Production and chemical processing of low molecular weight heparins.

13 July 2018

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Synthesis of heparin fragments: a methyl alpha-pentaoside with high affinity for antithrombin III.

13 July 2018

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USP compendial methods for analysis of heparin: chromatographic determination of molecular weight distributions for heparin sodium

13 July 2018

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Anomeric reactivity-based one-pot synthesis of heparin-like oligosaccharides

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4379424

Synthesis of complex carbohydrates and glycoconjugates: enzyme-based and programmable one-pot strategies

26 September 2018

1 reference

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The molecular-weight dependence of the rate-enhancing effect of heparin on the inhibition of thrombin, factor Xa, factor IXa, factor XIa, factor XIIa and kallikrein by antithrombin

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4379424

Bovine spongiform encephalopathy: epidemiological studies

26 September 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25817684

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CARBPOL.2014.10.054

1 reference

7 August 2017

1 reference

7 August 2017

1 reference