Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. (Q35234967)

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6 November 2019

title

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter (English)

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6 November 2019

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Matthew Bogyo

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author name string

Sukkid Yasothornsrikul

1

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Doron Greenbaum

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Katalin F Medzihradszky

3

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Thomas Toneff

4

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Richard Bundey

5

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Ruthellen Miller

6

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Birgit Schilling

7

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Ivonne Petermann

8

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Jessica Dehnert

9

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Anna Logvinova

10

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Paul Goldsmith

11

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John M Neveu

12

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William S Lane

13

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Bradford Gibson

14

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Christoph Peters

16

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Vivian Hook

18

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language of work or name

English

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publication date

17 July 2003

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Proceedings of the National Academy of Sciences of the United States of America

6 November 2019

published in

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volume

100

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issue

16

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page(s)

9590-9595

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Precursor convertases in the secretory pathway, cytosol and extracellular milieu

6 November 2019

cites work

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The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling

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Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.

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Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L.

13 July 2018

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Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

13 July 2018

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Processing of proenkephalin-A in bovine chromaffin cells. Identification of natural derived fragments by N-terminal sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry

13 July 2018

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Molecular mechanisms and regulation of opioid receptor signaling

13 July 2018

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Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs

13 July 2018

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Evidence for functional localization of the proenkephalin-processing enzyme, prohormone thiol protease, to secretory vesicles of chromaffin cells

13 July 2018

1 reference

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Proteolytic processing in the secretory pathway

13 July 2018

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Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates.

13 July 2018

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Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic beta-cells

13 July 2018

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Cysteine proteinases in GH4C1 cells, a rat pituitary tumor cell line, are secreted by the constitutive and regulated secretory pathways

13 July 2018

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Pharmacological mechanisms of opioid analgesics.

13 July 2018

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Proteases and the emerging role of protease inhibitors in prohormone processing.

13 July 2018

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"Prohormone thiol protease" (PTP) processing of recombinant proenkephalin

13 July 2018

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Post-translational proteolysis in polypeptide hormone biosynthesis

13 July 2018

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The enzymology and intracellular organization of peptide precursor processing: the secretory vesicle hypothesis

13 July 2018

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Appendix 5. Nomenclature for peptide fragment ions (positive ions).

13 July 2018

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Prohormone Thiol Protease and Enkephalin Precursor Processing: Cleavage at Dibasic and Monobasic Sites

13 July 2018

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Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice

13 July 2018

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The novel serpin endopin 2 demonstrates cross-class inhibition of papain and elastase: localization of endopin 2 to regulated secretory vesicles of neuroendocrine chromaffin cells

26 September 2018

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Evidence for the proenkephalin processing enzyme prohormone thiol protease (PTP) as a multicatalytic cysteine protease complex: activation by glutathione localized to secretory vesicles

26 September 2018

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Arginine and lysine aminopeptidase activities in chromaffin granules of bovine adrenal medulla: relevance to prohormone processing.

26 September 2018

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An investigation of the molecular properties and stability of intermediates of proenkephalin in isolated bovine adrenal medullary chromaffin granules

26 September 2018

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12 December 2020

Purification and characterization of a novel thiol protease involved in processing the enkephalin precursor

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12 December 2020

Epoxysuccinyl dipeptides as selective inhibitors of cathepsin B

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12 December 2020

Stimulation of "prohormone thiol protease" (PTP) and [Met]enkephalin by forskolin. Blockade of elevated [Met]enkephalin by a cysteine protease inhibitor of PTP

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12 December 2020

Influence of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) on the localization of cathepsin B and cathepsin L in human lung tumor cells

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1531542100

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6 November 2019

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6 November 2019

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