Molecular mechanism of transforming growth factor beta-mediated cell-cycle modulation in primary human CD34(+) progenitors (Q35242925)

7 August 2017

title

Molecular mechanism of transforming growth factor beta-mediated cell-cycle modulation in primary human CD34(+) progenitors (English)

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7 August 2017

Mo A Dao

1

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7 August 2017

Joseph Hwa

series ordinal

2

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7 August 2017

Jan A Nolta

series ordinal

3

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7 August 2017

language of work or name

English

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publication date

1 January 2002

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7 August 2017

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7 August 2017

volume

99

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7 August 2017

issue

2

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7 August 2017

page(s)

499-506

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Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.

7 August 2017

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Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G(2)/M transit and do not reenter G(0).

12 July 2018

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12 July 2018

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Molecular control of cell cycle progression in primary human hematopoietic stem cells: methods to increase levels of retroviral-mediated transduction

12 July 2018

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Transduction of human progenitor hematopoietic stem cells by human immunodeficiency virus type 1-based vectors is cell cycle dependent.

12 July 2018

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Abrogation of TGF-beta activity during retroviral transduction improves murine hematopoietic progenitor and repopulating cell gene transfer efficiency.

12 July 2018

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Functional association of TGF-beta receptor II with cyclin B

12 July 2018

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Retroviral transfer of the glucocerebrosidase gene into CD34+ cells from patients with Gaucher disease: in vivo detection of transduced cells without myeloablation

12 July 2018

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Adhesion to fibronectin maintains regenerative capacity during ex vivo culture and transduction of human hematopoietic stem and progenitor cells

12 July 2018

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Reduction in levels of the cyclin-dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells

12 July 2018

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TGF-beta signal transduction

12 July 2018

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The fluctuating phenotype of the lymphohematopoietic stem cell with cell cycle transit

12 July 2018

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T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates.

12 July 2018

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In vitro identification of single CD34+CD38- cells with both lymphoid and myeloid potential

12 July 2018

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Long-term cytokine production from engineered primary human stromal cells influences human hematopoiesis in an in vivo xenograft model

12 July 2018

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Functional heterogeneity of human CD34(+) cells isolated in subcompartments of the G0 /G1 phase of the cell cycle

12 July 2018

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Gene therapy for hematopoietic and immune disorders

12 July 2018

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Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice

12 July 2018

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Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells

12 July 2018

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TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest

12 July 2018

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

12 July 2018

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D-type cyclin-dependent kinase activity in mammalian cells

12 July 2018

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

12 July 2018

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Inhibition of cell growth by TGF beta 1 is associated with inhibition of B-myb and cyclin A in both BALB/MK and Mv1Lu cells.

12 July 2018

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Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells

12 July 2018

1 reference

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Transforming growth factor-beta regulates the cell cycle status of interleukin-3 (IL-3) plus IL-1, stem cell factor, or IL-6 stimulated CD34+ human hematopoietic progenitor cells through different cell kinetic mechanisms depending on the applied sti

12 July 2018

1 reference

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Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells

12 July 2018

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The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency

12 July 2018

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Retroviral vector-mediated gene transfer into primitive human hematopoietic progenitor cells: effects of mast cell growth factor (MGF) combined with other cytokines

12 July 2018

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TGF-(beta)1 maintains hematopoietic immaturity by a reversible negative control of cell cycle and induces CD34 antigen up-modulation.

12 July 2018

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Engraftment and retroviral marking of CD34+ and CD34+CD38- human hematopoietic progenitors assessed in immune-deficient mice.

26 September 2018

1 reference

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Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-beta but not macrophage inflammatory protein-1 alpha activities.

26 September 2018

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Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-beta.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382314

Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population

26 September 2018

1 reference

12 December 2020

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1 reference

12 December 2020

Release from quiescence of primitive human hematopoietic stem/progenitor cells by blocking their cell-surface TGF-beta type II receptor in a short-term in vitro assay

1 reference

12 December 2020

Discovery of a regulatory motif that controls the exposure of specific upstream cyclin-dependent kinase sites that determine both conformation and growth suppressing activity of pRb

1 reference

12 December 2020

TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes

1 reference

12 December 2020

Expression of G1-phase cell cycle genes during hematopoietic lineage

1 reference

12 December 2020

1 reference

12 December 2020

Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3: analysis of gene transduction of long-lived progenitors

1 reference

12 December 2020

TGF-beta 1 induces the cyclin-dependent kinase inhibitor p27Kip1 mRNA and protein in murine B cells

1 reference

12 December 2020

High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations

1 reference

12 December 2020

Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

1 reference

12 December 2020

Retroviral-mediated gene transduction of c-kit into single hematopoietic progenitor cells from cord blood enhances erythroid colony formation and decreases sensitivity to inhibition by tumor necrosis factor-alpha and transforming growth factor-beta1

1 reference

12 December 2020

Additive effects of steel factor and antisense TGF-beta 1 oligodeoxynucleotide on CD34+ hematopoietic progenitor cells

1 reference

12 December 2020

Stem cell engraftment and cell cycle phenotype

1 reference

12 December 2020

Identifiers

DOI

10.1182/BLOOD.V99.2.499

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7 August 2017

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7 August 2017

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