Evidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis (Q35252041)

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English	Evidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis	scientific article

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20 February 2020

Evidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis (English)

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20 February 2020

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Oliver Bachmann

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20 February 2020

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Dunja Bruder

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20 February 2020

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Sunil Yeruva

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20 February 2020

Giriprakash Chodisetti

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20 February 2020

Min Luo

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20 February 2020

Mingmin Chen

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20 February 2020

Ayhan Cinar

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20 February 2020

Lisa Ludolph

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20 February 2020

Maria Lünnemann

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20 February 2020

Julia Goldstein

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20 February 2020

Anurag Kumar Singh

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20 February 2020

Brigitte Riederer

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20 February 2020

Andre Bleich

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20 February 2020

Markus Gereke

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20 February 2020

Susan Hagen

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20 February 2020

Peijian He

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20 February 2020

Chris Yun

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20 February 2020

Ursula Seidler

18

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20 February 2020

publication date

2 October 2014

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20 February 2020

Pfluegers Archiv

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20 February 2020

467

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20 February 2020

1795-1807

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20 February 2020

8

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20 February 2020

copyright license

Creative Commons Attribution 4.0 International

2 October 2014

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April 2022 Public Data File from Crossref

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0 references

https://scigraph.springernature.com/pub.10.1007/s00424-014-1608-x

0 references

cAMP signaling in subcellular compartments

1 reference

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27 July 2018

Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3.

1 reference

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27 July 2018

Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling

1 reference

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27 July 2018

Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea.

1 reference

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27 July 2018

Loss of downregulated in adenoma (DRA) impairs mucosal HCO3(-) secretion in murine ileocolonic inflammation

1 reference

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27 July 2018

New therapeutic targets in ulcerative colitis: the importance of ion transporters in the human colon.

1 reference

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27 July 2018

Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice

1 reference

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27 July 2018

Preserved Na(+)/H(+) exchanger isoform 3 expression and localization, but decreased NHE3 function indicate regulatory sodium transport defect in ulcerative colitis

1 reference

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27 July 2018

Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3

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27 July 2018

Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2.

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27 July 2018

Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: a novel model for studying the pathomechanisms of inflammatory bowel disease cytokines

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27 July 2018

NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

27 July 2018

NHE3 regulatory complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

27 July 2018

Tethering, recycling and activation of the epithelial sodium-proton exchanger, NHE3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

27 July 2018

Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

27 July 2018

Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

27 July 2018

IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

27 July 2018

Defective jejunal and colonic salt absorption and alteredNa(+)/H (+) exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

27 July 2018

The acid-activated signaling pathway: starting with Pyk2 and ending with increased NHE3 activity

1 reference

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27 July 2018

Regulatory binding partners and complexes of NHE3.

1 reference

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27 July 2018

Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

27 July 2018

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

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27 July 2018

Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

27 July 2018

Exposure of the rat small intestine to raw kidney beans results in reorganization of absorptive cell microvilli

1 reference

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27 July 2018

Downregulation of the NHE3-binding PDZ-adaptor protein PDZK1 expression during cytokine-induced inflammation in interleukin-10-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

Altered ENaC expression leads to impaired sodium absorption in the noninflamed intestine in Crohn's disease.

1 reference

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26 September 2018

Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions.

1 reference

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26 September 2018

The emerging role of PDZ adapter proteins for regulation of intestinal ion transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

Protein/protein interactions (PDZ) in proximal tubules

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

Refined histopathologic scoring system improves power to detect colitis QTL in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

The Na+/H+ exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

A new mathematical model for relative quantification in real-time RT-PCR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

Upregulation of CFTR expression but not SLC26A3 and SLC9A3 in ulcerative colitis

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383727

26 September 2018

https://api.crossref.org/works/10.1007%2FS00424-014-1608-X

21 January 2018

Increased epithelial permeability is the primary cause for bicarbonate loss in inflamed murine colon

1 reference

https://pubmed.ncbi.nlm.nih.gov/25271043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down regulation of small intestinal ion transport in PDZK1- (CAP70/NHERF3) deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25271043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NHE3 inhibition by cAMP and Ca2+ is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25271043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00424-014-1608-X

1 reference

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20 February 2020

1 reference

Europe PubMed Central

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20 February 2020

1 reference

Europe PubMed Central

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20 February 2020

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