Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease (Q35268092)

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7 February 2020

title

Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease (English)

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7 February 2020

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2

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7 February 2020

Ferdinando Squitieri

7

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7 February 2020

9

M Flint Beal

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7 February 2020

author name string

Ashu Johri

1

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7 February 2020

Abhishek Chandra

3

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7 February 2020

Thomas Hennessey

4

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7 February 2020

Abhijeet Sharma

5

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7 February 2020

Sara Orobello

6

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7 February 2020

Lichuan Yang

8

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7 February 2020

publication date

15 July 2011

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Neurodegenerative Diseases

7 February 2020

published in

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7 February 2020

volume

8

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7 February 2020

issue

6

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7 February 2020

page(s)

496-503

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Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

7 February 2020

cites work

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Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186722

Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186722

SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186722

Impaired PGC-1alpha function in muscle in Huntington's disease.

12 July 2018

1 reference

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Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise

12 July 2018

1 reference

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Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways

12 July 2018

1 reference

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

12 July 2018

1 reference

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PGC-1alpha, a new therapeutic target in Huntington's disease?

12 July 2018

1 reference

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Oxidative damage in Huntington's disease pathogenesis

12 July 2018

1 reference

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Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186722

Increased apoptosis, Huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington's disease subjects

12 July 2018

1 reference

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Mitochondria take center stage in aging and neurodegeneration

12 July 2018

1 reference

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

12 July 2018

1 reference

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

12 July 2018

1 reference

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The energetics of Huntington's disease

12 July 2018

1 reference

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Transcriptional abnormalities in Huntington disease

12 July 2018

1 reference

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12 July 2018

1 reference

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186722

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

12 July 2018

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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

21 January 2018

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Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice

21 January 2018

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Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis

21 January 2018

1 reference

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.

21 January 2018

1 reference

Identification and characterization of an alternative promoter of the human PGC-1alpha gene

21 January 2018

1 reference

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

1 reference

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000327910

1 reference

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7 February 2020

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7 February 2020

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