Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR (Q35275697)

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14 February 2020

title

Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR (English)

1 reference

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14 February 2020

0 references

2

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14 February 2020

Luke Leman

7

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14 February 2020

author name string

Darren M Hutt

1

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14 February 2020

Chris J Vickers

3

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14 February 2020

David Herman

4

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14 February 2020

Monica Chalfant

5

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14 February 2020

Ana Montero

6

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14 February 2020

Renner Burkle

8

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14 February 2020

Bruce E Maryanoff

9

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14 February 2020

William E Balch

10

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14 February 2020

M Reza Ghadiri

11

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publication date

1 July 2011

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ACS Medicinal Chemistry Letters

14 February 2020

published in

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volume

2

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issue

9

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14 February 2020

page(s)

703-707

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Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR.

14 February 2020

cites work

1 reference

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Combating cystic fibrosis: in search for CF transmembrane conductance regulator (CFTR) modulators

12 July 2018

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Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles

12 July 2018

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Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine.

12 July 2018

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Chemical phylogenetics of histone deacetylases

12 July 2018

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Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

12 July 2018

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The proteostasis boundary in misfolding diseases of membrane traffic

12 July 2018

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Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides

12 July 2018

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Biological and chemical approaches to diseases of proteostasis deficiency

12 July 2018

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Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.

12 July 2018

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Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures.

12 July 2018

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Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy

12 July 2018

1 reference

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CFTR function and prospects for therapy

12 July 2018

1 reference

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Adapting proteostasis for disease intervention

12 July 2018

1 reference

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Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases

12 July 2018

1 reference

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The epigenetic signature of CFTR expression is co-ordinated via chromatin acetylation through a complex intronic element.

12 July 2018

1 reference

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Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytes

12 July 2018

1 reference

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Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187562

Anticancer activities of histone deacetylase inhibitors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187562

Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187562

Rescue of DeltaF508 and other misprocessed CFTR mutants by a novel quinazoline compound

12 July 2018

1 reference

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Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187562

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

12 July 2018

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12 July 2018

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Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker

12 July 2018

1 reference

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Cystic fibrosis: a worldwide analysis of CFTR mutations--correlation with incidence data and application to screening

12 July 2018

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

12 July 2018

1 reference

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Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

12 July 2018

1 reference

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Cystic fibrosis problem probed by proteolysis

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21984958

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Transcriptional repression of the cystic fibrosis transmembrane conductance regulator gene, mediated by CCAAT displacement protein/cut homolog, is associated with histone deacetylation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21984958

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Histone deacetylase inhibitors selectively suppress expression of HDAC7

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21984958

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML200136E

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984958%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

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14 February 2020

PubMed publication ID

21984958

1 reference