Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine (Q35277863)

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scientific article published on December 31, 1992

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English	Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine	scientific article published on December 31, 1992

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scholarly article

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7 August 2017

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Europe PubMed Central

Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine (English)

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Europe PubMed Central

7 August 2017

Alzheimer's disease

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post-translational protein modification

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18 September 2022

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Greengard P

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J. D. Buxbaum

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A. C. Nairn

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18 September 2022

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S. E. Gandy

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G. L. Caporaso

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T. V. Ramabhadran

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T. Suzuki

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C. Nordstedt

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K. Iverfeldt

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A. J. Czernik

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1 December 1992

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31 December 1992

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18 September 2022

Annals of the New York Academy of Sciences

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7 August 2017

674

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203-217

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Europe PubMed Central

7 August 2017

New perspectives on Alzheimer's disease

1 reference

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Aberrant neurofilament phosphorylation in Alzheimer disease

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

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Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

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Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

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A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

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Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

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Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

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Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II.

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Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors

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Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process

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Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms

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Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

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Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

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21 January 2018

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein

1 reference

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21 January 2018

The molecular pathology of Alzheimer's disease

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Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

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Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities

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21 January 2018

Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment

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21 January 2018

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

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Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

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Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels

1 reference

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21 January 2018

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

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Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment

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Formation of beta-amyloid protein deposits in brains of transgenic mice

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Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Mis-sense mutation Val&rarr;Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease

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Amyloid beta protein enhances the survival of hippocampal neurons in vitro

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Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

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Identifiers

10.1111/J.1749-6632.1992.TB27489.X

1 reference

Europe PubMed Central

7 August 2017

1 reference

Europe PubMed Central

7 August 2017

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