Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer (Q35289038)

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English	Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer	scientific article

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scholarly article

1 reference

Europe PubMed Central

7 August 2017

Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer (English)

1 reference

Europe PubMed Central

7 August 2017

0 references

1 reference

ChEBI release 2020-05-28

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

5

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7

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author name string

Jordi Rodón

1

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12 June 2020

Michael Carducci

2

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12 June 2020

Juan M Sepulveda-Sánchez

3

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Analía Azaro

4

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Elisabet Sicart

8

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12 June 2020

Ivelina Gueorguieva

9

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12 June 2020

Ann Cleverly

10

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12 June 2020

N Sokalingum Pillay

11

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12 June 2020

Durisala Desaiah

12

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12 June 2020

Shawn T Estrem

13

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12 June 2020

Luis Paz-Ares

14

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Matthias Holdhoff

15

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12 June 2020

Jaishri Blakeley

16

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12 June 2020

Michael M Lahn

17

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12 June 2020

Jose Baselga

18

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12 June 2020

publication date

23 December 2014

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7 August 2017

Investigational New Drugs

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33

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357-370

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2

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copyright license

Creative Commons Attribution 4.0 International

23 December 2014

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April 2022 Public Data File from Crossref

copyright status

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https://scigraph.springernature.com/pub.10.1007/s10637-014-0192-4

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First-in-human dose study of the novel transforming growth factor-β receptor I kinase inhibitor LY2157299 monohydrate in patients with advanced cancer and glioma

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Defining a therapeutic window for the novel TGF-β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model

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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

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Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapy

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TGF-β: the sword, the wand, and the shield of FOXP3(+) regulatory T cells

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Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761.

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Pro- and anti-inflammatory cytokines during immune stimulation: modulation of iron status and red blood cell profile

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TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma

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Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

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Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2.

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Influence of enzyme-inducing antiepileptic drugs on trough level of imatinib in glioblastoma patients

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SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

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10.1007/S10637-014-0192-4

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12 June 2020

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12 June 2020

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12 June 2020

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