NADPH oxidases: not just for leukocytes anymore! (Q35296159)

7 August 2017

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title

NADPH oxidases: not just for leukocytes anymore! (English)

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7 August 2017

Gary M Bokoch

1

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PubMed ID

13678962

7 August 2017

Ulla G Knaus

series ordinal

2

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7 August 2017

1 September 2003

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7 August 2017

7

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Trends in Biochemical Sciences

inferred from page(s)

published in

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7 August 2017

28

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7 August 2017

502-508

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7 August 2017

9

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Potential drug targets: small GTPases that regulate leukocyte function

7 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Regulation of neutrophil function by Rac GTPases

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Molecular basis of phosphorylation-induced activation of the NADPH oxidase

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby acti

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

NADPH oxidase activity is independent of p47phox in vitro

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

The cytosolic component p47(phox) is not a sine qua non participant in the activation of NADPH oxidase but is required for optimal superoxide production

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

PX domains: attracted by phosphoinositides

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Regulation of the neutrophil respiratory burst oxidase. Identification of an activation domain in p67(phox).

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

The active N-terminal region of p67phox. Structure at 1.8 A resolution and biochemical characterizations of the A128V mutant implicated in chronic granulomatous disease

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558)

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Ras effector-homologue region on Rac regulates protein associations in the neutrophil respiratory burst oxidase complex

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Structure of the TPR domain of p67phox in complex with Rac.GTP

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

"Peptide walking" is a novel method for mapping functional domains in proteins. Its application to the Rac1-dependent activation of NADPH oxidase

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Molecular basis for Rac2 regulation of phagocyte NADPH oxidase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Mutational analysis of novel effector domains in Rac1 involved in the activation of nicotinamide adenine dinucleotide phosphate (reduced) oxidase

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Activation of the superoxide-generating NADPH oxidase by chimeric proteins consisting of segments of the cytosolic component p67(phox) and the small GTPase Rac1.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

A Rac1 effector site controlling mitogenesis through superoxide production.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Redox-dependent downregulation of Rho by Rac.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Current molecular models for NADPH oxidase regulation by Rac GTPase

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Novel homologs of gp91phox.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

A plant homolog of the neutrophil NADPH oxidase gp91phox subunit gene encodes a plasma membrane protein with Ca2+ binding motifs.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Identification of renox, an NAD(P)H oxidase in kidney

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

A novel superoxide-producing NAD(P)H oxidase in kidney

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Cell transformation by the superoxide-generating oxidase Mox1

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Type I Helicobacter pylori lipopolysaccharide stimulates toll-like receptor 4 and activates mitogen oxidase 1 in gastric pit cells

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Reactive oxygen generated by Nox1 triggers the angiogenic switch

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Reactive oxygen species produced by NADPH oxidase regulate plant cell growth

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Two novel proteins activate superoxide generation by the NADPH oxidase NOX1

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Protection from reoxygenation injury by inhibition of rac1.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900194-4

7 January 2021

10.1016/S0968-0004(03)00194-4

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

13678962