Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation (Q35311960)

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9 February 2020

title

Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation (English)

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9 February 2020

1

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9 February 2020

author name string

Ganes C Sen

series ordinal

2

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9 February 2020

George R Stark

series ordinal

3

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9 February 2020

Saurabh Chattopadhyay

series ordinal

4

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9 February 2020

language of work or name

English

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publication date

4 August 2011

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Journal of Biological Chemistry

9 February 2020

published in

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9 February 2020

volume

286

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9 February 2020

issue

38

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9 February 2020

page(s)

33037-33044

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RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein

9 February 2020

cites work

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Phosphatidylinositol 3-kinase signaling delays sendai virus-induced apoptosis by preventing XIAP degradation

12 July 2018

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The IRF-3/Bax-mediated apoptotic pathway, activated by viral cytoplasmic RNA and DNA, inhibits virus replication

12 July 2018

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The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3.

12 July 2018

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Viral apoptosis is induced by IRF-3-mediated activation of Bax

12 July 2018

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Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3

12 July 2018

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Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

12 July 2018

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12 July 2018

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IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation

12 July 2018

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Identification of Caspase-mediated Decay of Interferon Regulatory Factor-3, Exploited by a Kaposi Sarcoma-associated Herpesvirus Immunoregulatory Protein

12 July 2018

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TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response

12 July 2018

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Nonproteolytic functions of ubiquitin in cell signaling

12 July 2018

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Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

12 July 2018

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The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3

12 July 2018

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Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression

12 July 2018

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S-glutathionylation of IRF3 regulates IRF3-CBP interaction and activation of the IFN beta pathway

12 July 2018

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IRF-3 activation by Sendai virus infection is required for cellular apoptosis and avoidance of persistence

12 July 2018

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12 July 2018

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Caspase-8-mediated apoptosis in human RPE cells

12 July 2018

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Ubiquitination and proteasomal degradation of interferon regulatory factor-3 induced by Npro from a cytopathic bovine viral diarrhea virus

12 July 2018

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SVM-based prediction of caspase substrate cleavage sites

12 July 2018

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The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) induces degradation of interferon response factor 3 and, consequently, inhibits beta interferon promoter activity

12 July 2018

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Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation

12 July 2018

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ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation.

12 July 2018

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Essential role of IPS-1 in innate immune responses against RNA viruses

12 July 2018

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Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.

12 July 2018

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Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA

12 July 2018

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Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-kappaB, and interferon but not toll-like receptor 3

12 July 2018

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12 July 2018

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

12 July 2018

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12 July 2018

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12 July 2018

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RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.

12 July 2018

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A mutant cell line defective in response to double-stranded RNA and in regulating basal expression of interferon-stimulated genes

12 July 2018

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Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation

12 July 2018

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ARPE-19, a human retinal pigment epithelial cell line with differentiated properties

12 July 2018

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Characterization of a newly derived human sarcoma cell line (HT-1080).

12 July 2018

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The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases

12 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.257022

CASVM: web server for SVM-based prediction of caspase substrates cleavage sites

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.257022

21 January 2018

Identifiers

DOI

10.1074/JBC.M111.257022

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816816%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21816816%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

21816816

1 reference