Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling. (Q35345071)

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13 February 2020

title

Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling (English)

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13 February 2020

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11

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13 February 2020

author name string

Alix Scholer-Dahirel

1

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Michael R Schlabach

2

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Alice Loo

3

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Linda Bagdasarian

4

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13 February 2020

Ronald Meyer

5

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Ribo Guo

6

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Steve Woolfenden

7

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Kristine K Yu

8

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Judit Markovits

9

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13 February 2020

Karen Killary

10

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13 February 2020

Yung-Mae Yao

12

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13 February 2020

Markus Warmuth

13

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William R Sellers

14

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Robert Schlegel

15

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13 February 2020

Frank Stegmeier

16

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13 February 2020

Rebecca E Mosher

17

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Margaret E McLaughlin

18

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13 February 2020

language of work or name

English

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publication date

23 September 2011

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Proceedings of the National Academy of Sciences of the United States of America

13 February 2020

published in

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volume

108

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issue

41

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page(s)

17135-17140

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

13 February 2020

cites work

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Identification of stem cells in small intestine and colon by marker gene Lgr5

12 July 2018

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Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

12 July 2018

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Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

12 July 2018

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Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells

12 July 2018

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Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

12 July 2018

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The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

12 July 2018

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Casein kinase 1: a Wnt'er of disconnect

12 July 2018

1 reference

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Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation

12 July 2018

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Coordinating cell proliferation and differentiation

12 July 2018

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Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

12 July 2018

1 reference

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Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation

12 July 2018

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Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

12 July 2018

1 reference

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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

12 July 2018

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Identification of c-MYC as a target of the APC pathway

12 July 2018

1 reference

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Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

12 July 2018

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Stabilization of beta-catenin by genetic defects in melanoma cell lines

12 July 2018

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

12 July 2018

1 reference

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

12 July 2018

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A Tetraspan Membrane Glycoprotein Produced in the Human Intestinal Epithelium and Liver That Can Regulate Cell Density-dependent Proliferation

12 July 2018

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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

12 July 2018

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A genetic model for colorectal tumorigenesis

12 July 2018

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APC mutations occur early during colorectal tumorigenesis

12 July 2018

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Detection of point mutations of the Axin1 gene in colorectal cancers

12 July 2018

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Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

26 September 2018

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Colorectal Tumors Are Effectively Eradicated by Combined Inhibition of -Catenin, KRAS, and the Oncogenic Transcription Factor ITF2

26 September 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1104182108

Differential apomucin expression in normal and neoplastic human gastrointestinal tissues

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21949247

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21949247

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1104182108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21949247%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

0 references

1 reference

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13 February 2020

PubMed publication ID

21949247

1 reference