IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-gamma dependent manner (Q35362225)

7 August 2017

title

IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-gamma dependent manner (English)

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7 August 2017

Chikano S

1

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7 August 2017

Sawada K

2

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7 August 2017

Shimoyama T

3

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7 August 2017

Kashiwamura SI

4

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7 August 2017

Sugihara A

5

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7 August 2017

Sekikawa K

6

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7 August 2017

Terada N

7

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7 August 2017

Nakanishi K

8

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7 August 2017

Okamura H

9

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7 August 2017

language of work or name

English

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publication date

1 December 2000

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7 August 2017

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7 August 2017

volume

47

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7 August 2017

issue

6

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7 August 2017

page(s)

779-786

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IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

7 August 2017

cites work

1 reference

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IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response

27 July 2018

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Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines

27 July 2018

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IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes.

27 July 2018

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T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

27 July 2018

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Defective NK cell activity and Th1 response in IL-18-deficient mice

27 July 2018

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CD45RBhigh CD4+ T cells from IFN-gamma knockout mice do not induce wasting disease

27 July 2018

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IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.

27 July 2018

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Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells.

27 July 2018

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Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation

27 July 2018

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IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.

27 July 2018

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IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.

27 July 2018

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27 July 2018

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A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

27 July 2018

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Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein

27 July 2018

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CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells

27 July 2018

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Acquisition of lymphokine-producing phenotype by CD4+ T cells

27 July 2018

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Nitric oxide protects against alkyl peroxide-mediated cytotoxicity: further insights into the role nitric oxide plays in oxidative stress

27 July 2018

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Nitric oxide induces apoptosis in mouse thymocytes.

27 July 2018

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Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

27 July 2018

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TNF-alpha and IFN-gamma stimulate a macrophage precursor cell line to kill Listeria monocytogenes in a nitric oxide-independent manner.

27 July 2018

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Cloning of a new cytokine that induces IFN-gamma production by T cells

27 July 2018

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Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice

27 July 2018

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Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition

27 July 2018

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The biology of cachectin/TNF--a primary mediator of the host response

27 July 2018

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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

27 July 2018

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Interactions between endogenous gamma interferon and tumor necrosis factor in host resistance against primary and secondary Listeria monocytogenes infections

27 July 2018

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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

27 July 2018

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Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells

27 July 2018

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Nitric oxide: physiology, pathophysiology, and pharmacology

27 July 2018

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DNA damage and mutation in human cells exposed to nitric oxide in vitro

27 July 2018

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Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4.

27 July 2018

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Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

26 September 2018

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Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

26 September 2018

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Cytokine gene expression of endothelial cells infected with Trypanosoma cruzi

26 September 2018

1 reference

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A pivotal role of IL-12 in Th1-dependent mouse liver injury

15 November 2018

1 reference

12 December 2020

Propionibacterium acnes treatment diminishes CD4+ NK1.1+ T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells

1 reference

12 December 2020

Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes

1 reference

12 December 2020

A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma

1 reference

12 December 2020

IL-18 accounts for both TNF-alpha- and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice

1 reference

12 December 2020

Interleukin-18: a novel cytokine that augments both innate and acquired immunity

1 reference

12 December 2020

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production

1 reference

12 December 2020

IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma

1 reference

12 December 2020

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine

1 reference

12 December 2020

High serum IL-6 level reflects susceptible status of the host to endotoxin and IL-1/tumor necrosis factor

1 reference

12 December 2020

Importance of direct hepatocytolysis by liver macrophages in experimental fulminant hepatitis

1 reference

12 December 2020

Severe colitis in mice with aberrant thymic selection

1 reference

12 December 2020

Identifiers

DOI

10.1136/GUT.47.6.779

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7 August 2017

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7 August 2017

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