Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery (Q35415314)

8 August 2017

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title

Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery (English)

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8 August 2017

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J. P. Bai

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1409387

23 September 2022

G. L. Amidon

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1409387

23 September 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1409387

23 September 2022

publication date

1 August 1992

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8 August 2017

Pharmaceutical Research

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8 August 2017

9

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8 August 2017

8

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8 August 2017

969-978

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Improved delivery through biological membranes. 4. Prodrugs of L-dopa

8 August 2017

1 reference

12 December 2020

Peptide hydrolases of the human small intestinal mucosa: distribution of activities between brush border membranes and cytosol

1 reference

12 December 2020

Intestinal absorption of dipeptides and beta-lactam antibiotics. II. Purification of the binding protein for dipeptides and beta-lactam antibiotics from rabbit small intestinal brush border membranes

1 reference

12 December 2020

Characterization of human tissue carnosinase

1 reference

12 December 2020

Studies on a wide-spectrum intestinal dipeptide uptake system in the monkey and in the human

1 reference

12 December 2020

Evidence of a specialized transport mechanism for the intestinal absorption of baclofen.

1 reference

12 December 2020

A Common Mechanism for Transport of Di- and Tri-Peptides by Hamster Jejunum in Vitro

1 reference

12 December 2020

Intestinal Mucosal Hydrolysis of Proteins and Peptides

1 reference

12 December 2020

Evidence for Active Transport of Tripeptides by Hamster Jejunum in Vitro

1 reference

12 December 2020

Intestinal surface amino-oligopeptidases. II. Substrate kinetics and topography of the active site

1 reference

12 December 2020

Utilization of peptide carrier system to improve intestinal absorption: targeting prolidase as a prodrug-converting enzyme

1 reference

12 December 2020

Role of rat intestinal brush-border membrane angiotensin-converting enzyme in dietary protein digestion

1 reference

12 December 2020

Novel activity of human angiotensin I converting enzyme: release of the NH2- and COOH-terminal tripeptides from the luteinizing hormone-releasing hormone

1 reference

12 December 2020

The absorption of insulin from various regions of the rat intestine

1 reference

12 December 2020

Evidence for a carrier-mediated transport system in the small intestine available for FK089, a new cephalosporin antibiotic without an amino group

1 reference

12 December 2020

Use of the peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa

1 reference

12 December 2020

An amphiphilic form of dipeptidyl peptidase IV from pig small-intestinal brush-border membrane. Purification by immunoadsorbent chromatography and some properties

1 reference

12 December 2020

Stereospecific absorption and degradation of cephalexin

1 reference

12 December 2020

Longitudinal study of the human intestinal brush border membrane proteins. Distribution of the main disaccharidases and peptidases

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12 December 2020

Intestinal Absorption of Stereoisomers of Dipeptides in the Rat

1 reference

12 December 2020

Dipeptidylaminopeptidase and carboxypeptidase activities of the brush border of rabbit small intestine

1 reference

12 December 2020

γ-Glutamyl Transpeptidase of Rat Intestine: Localization and Possible Role in Amino Acid Transport

1 reference

12 December 2020

A micro-electrode study of oligopeptide absorption by the small intestinal epithelium of Necturus maculosus.

1 reference

12 December 2020

Human intestinal brush border angiotensin-converting enzyme activity and its inhibition by antihypertensive Ramipril

1 reference

12 December 2020

Bestatin inhibition of human tissue carnosinase, a non-specific cytosolic dipeptidase

1 reference

12 December 2020

Swine kidney prolidase: assay, isolation procedure, and molecular properties

1 reference

12 December 2020

The effect of pH and concentration on alpha-methyldopa absorption in man.

1 reference

12 December 2020

Structural requirements for the intestinal mucosal-cell peptide transporter: the need for N-terminal alpha-amino group

1 reference

12 December 2020

Intestinal absorption mechanisms of thyrotropin-releasing hormone

1 reference

12 December 2020

Aminotripeptidase, a cytosol enzyme from rabbit intestinal mucosa

1 reference

12 December 2020

Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and beta-lactam antibiotics

1 reference

12 December 2020

Cleavage of the Arg1-Pro2 bond of bradykinin by a human lung peptidase: isolation, characterization, and inhibition by several beta-lactam antibiotics.

1 reference

12 December 2020

Proteolytic inactivation of substance P in the epithelial layer of the intestine.

1 reference

12 December 2020

Hydrolysis of substance P and its analogs by angiotensin-converting enzyme from rat lung. Characterization of endopeptidase activity of the enzyme

1 reference

12 December 2020

Intestinal transport of amino acid residues of dipeptides. I. Influx of the glycine residue of glycyl-L-proline across mucosal border

1 reference

12 December 2020

Is intestinal peptide transport energized by a proton gradient?

1 reference

12 December 2020

Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: enalapril and fosinopril

1 reference

12 December 2020

Immunoelectrophoretic studies on human small intestinal brush border proteins—the longitudinal distribution of peptidases and disaccharidases

1 reference

12 December 2020

Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium

1 reference

12 December 2020

The transport of an intact oligopeptide across adult mammalian jejunum

1 reference

12 December 2020

Oral absorption of peptides: influence of pH and inhibitors on the intestinal hydrolysis of leu-enkephalin and analogues

1 reference

12 December 2020

Human erythrocyte prolidase and prolidase deficiency

1 reference

12 December 2020

Characterization of the oral absorption of beta-lactam antibiotics. II. Competitive absorption and peptide carrier specificity.

1 reference

12 December 2020

Microvillus membrane peptidases that catalyze hydrolysis of cysteinylglycine and its derivatives

1 reference

12 December 2020

Prolidase from bovine intestine: purification and characterization

1 reference

12 December 2020

Topology of microvillar membrance hydrolases of kidney and intestine

1 reference

12 December 2020

Isolation of endopeptidase-24.11 (EC 3.4.24.11, "enkephalinase") from the pig stomach. Hydrolysis of substance P, gastrin-releasing peptide 10, [Leu5] enkephalin, and [Met5] enkephalin

1 reference

12 December 2020

Rat intestinal brush border membrane peptidases. I. Solubilization, purification, and physicochemical properties of two different forms of the enzyme

1 reference

12 December 2020

Distribution and biosynthesis of aminopeptidase n and dipeptidyl aminopeptidase IV in rat small intestine

1 reference

12 December 2020

H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine.

1 reference

12 December 2020

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12 December 2020

Human intestinal brush border peptidases

1 reference

12 December 2020

Transport mechanisms of bestatin in rabbit intestinal brush-border membranes: role of H+/dipeptide cotransport system.

1 reference

12 December 2020

Evidence suggesting that some proteolytic enzymes may cleave only the trans form of the peptide bond

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12 December 2020

Specific transfer process for intestinal absorption of peptides

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12 December 2020

Is the proline-specific aminopeptidase P of the intestinal brush border an integral membrane enzyme?

1 reference

12 December 2020

Simultaneous isolation of brush border and basolateral membrane from rabbit enterocytes. Presence of brush border hydrolases in the basolateral membrane of rabbit enterocytes

1 reference

12 December 2020

Characterization of the oral absorption of beta-lactam antibiotics. I. Cephalosporins: determination of intrinsic membrane absorption parameters in the rat intestine in situ.

1 reference

12 December 2020

Structural properties of pig intestinal proline dipeptidase

1 reference

12 December 2020

Digestion and assimilation of proline-containing peptides by rat intestinal brush border membrane carboxypeptidases. Role of the combined action of angiotensin-converting enzyme and carboxypeptidase P.

1 reference

12 December 2020

Proline specific endo- and exopeptidases

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12 December 2020

Intestinal absorption mechanism of dipeptide angiotensin converting enzyme inhibitors of the lysyl-proline type: lisinopril and SQ 29,852

1 reference

12 December 2020

Transport of glycyl-L-proline by human intestinal brush border membrane vesicles

1 reference

12 December 2020

Aminopeptidase P activity in rat organs and human serum

1 reference

12 December 2020

Prolidase and prolidase deficiency

1 reference

12 December 2020

Enzymic properties of intestinal aminopeptidase P: a new continuous assay

1 reference

12 December 2020

Active Transport of L-Dopa in the Intestine

1 reference

12 December 2020

Competition between carnosine and other peptides for transport by hamster jejunum in vitro.

1 reference

12 December 2020

Uptake of Dipeptides Containing Basic and Acidic Amino Acids by Rat Small Intestine in Vitro

1 reference

12 December 2020

A neutral endopeptidase in the microvillar membrane of pig intestine. Partial purification and properties

1 reference

12 December 2020

Passive and carrier-mediated intestinal absorption components of captopril

1 reference

12 December 2020

Rat intestinal brush border membrane peptidases. II. Enzymatic properties, immunochemistry, and interactions with lectins of two different forms of the enzyme

1 reference

12 December 2020

Vasopressin: a model for the study of effects of additives on the oral and rectal administration of peptide drugs

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1015885823793

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8 August 2017

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