Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events (Q35470364)

8 August 2017

title

Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events (English)

1 reference

8 August 2017

Brian J Conti

1

1 reference

8 August 2017

Prasanna K Devaraneni

2

1 reference

8 August 2017

Zhongying Yang

3

1 reference

8 August 2017

Larry L David

4

1 reference

8 August 2017

William R Skach

5

1 reference

8 August 2017

publication date

19 March 2015

1 reference

8 August 2017

1 reference

8 August 2017

volume

58

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8 August 2017

issue

2

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8 August 2017

page(s)

269-283

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Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

8 August 2017

cites work

1 reference

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Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex

12 July 2018

1 reference

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Sec62 protein mediates membrane insertion and orientation of moderately hydrophobic signal anchor proteins in the endoplasmic reticulum (ER)

12 July 2018

1 reference

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Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria

12 July 2018

1 reference

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Co-translational targeting and translocation of proteins to the endoplasmic reticulum.

12 July 2018

1 reference

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Structure and 3D arrangement of endoplasmic reticulum membrane-associated ribosomes.

12 July 2018

1 reference

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Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

12 July 2018

1 reference

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Mechanisms of Sec61/SecY-mediated protein translocation across membranes

12 July 2018

1 reference

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Signal peptidase I: cleaving the way to mature proteins

12 July 2018

1 reference

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Transmembrane segments of nascent polytopic membrane proteins control cytosol/ER targeting during membrane integration

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Membrane protein insertion at the endoplasmic reticulum

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

In vitro methods for CFTR biogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Evolutionary gain of function for the ER membrane protein Sec62 from yeast to humans

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Cellular mechanisms of membrane protein folding

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

The lateral gate of SecYEG opens during protein translocation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

An evolving view of the eukaryotic oligosaccharyltransferase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

X-ray structure of a protein-conducting channel

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

A new role for BiP: closing the aqueous translocon pore during protein integration into the ER membrane

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Mammalian Sec61 is associated with Sec62 and Sec63

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

A signal sequence receptor in the endoplasmic reticulum membrane

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Unusual topogenic sequence directs prion protein biogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

A protein of the endoplasmic reticulum involved early in polypeptide translocation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

The Sec62-Sec63 translocon facilitates translocation of the C-terminus of membrane proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Endoplasmic reticulum-bound ribosomes reside in stable association with the translocon following termination of protein synthesis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Translocational pausing is a common step in the biogenesis of unconventional integral membrane and secretory proteins.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

The 70 carboxyl-terminal amino acids of nascent secretory proteins are protected from proteolysis by the ribosome and the protein translocation apparatus of the endoplasmic reticulum membrane.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

TRAP assists membrane protein topogenesis at the mammalian ER membrane

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

Architecture of the Ribosome–Channel Complex Derived from Native Membranes

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402133

J proteins catalytically activate Hsp70 molecules to trap a wide range of peptide sequences

15 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25801167

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ribosome-independent regulation of translocon composition and Sec61alpha conformation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25801167

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25801167

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2015.02.018

1 reference

8 August 2017

1 reference

8 August 2017

1 reference