UDP glucuronosyltransferase family 1 member A1 (Q3547204)

http://www.ebi.ac.uk/interpro/protein/P22309

UDP-glycosyltransferase family, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

enzyme inhibitor activity

1 reference

8 April 2019

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans

retinoic acid binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

hexosyltransferase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

protein homodimerization activity

1 reference

8 April 2019

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

glycosyltransferase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

1 reference

8 April 2019

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

protein heterodimerization activity

2 references

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

glucuronosyltransferase activity

12 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

UDP-glycosyltransferase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

glucuronosyltransferase activity

IBA

10 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 January 2018

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 January 2018

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 January 2018

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 January 2018

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 January 2018

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 January 2018

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 January 2018

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

protein heterodimerization activity

1 reference

8 April 2019

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

glucuronosyltransferase activity

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

endoplasmic reticulum membrane

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

integral component of plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

endoplasmic reticulum chaperone complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

endoplasmic reticulum

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

endoplasmic reticulum

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

intracellular membrane-bounded organelle

3 references

steroid metabolic process

1 reference

8 April 2019

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

cellular response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

estrogen metabolic process

1 reference

8 April 2019

cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

negative regulation of steroid metabolic process

1 reference

8 April 2019

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

response to steroid hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

response to glucocorticoid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

retinoic acid metabolic process

1 reference

8 April 2019

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

negative regulation of cellular glucuronidation

1 reference

27 February 2018

Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

response to organic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

cellular response to hormone stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

heme catabolic process

1 reference

8 April 2019

cellular response to glucocorticoid stimulus

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

heterocycle metabolic process

1 reference

8 April 2019

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

animal organ regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

response to starvation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

flavone metabolic process

1 reference

8 April 2019

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

negative regulation of glucuronosyltransferase activity

1 reference

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

negative regulation of fatty acid metabolic process

1 reference

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

biphenyl catabolic process

ISS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

cellular response to estradiol stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

cellular glucuronidation

5 references

27 February 2018

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

27 February 2018

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22309&geneProductId=UniProtKB:P22309

cellular response to xenobiotic stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

negative regulation of catalytic activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

cellular glucuronidation

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

flavonoid glucuronidation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

xenobiotic glucuronidation

IBA

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22309

UDP-glycosyltransferase family, conserved site

IBA

has part(s)

1 reference

stated in

InterPro Release 71.0