A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients (Q35484320)

8 August 2017

A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients (English)

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8 August 2017

P J Tyrrell

7

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author name string

H C A Emsley

1

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8 August 2017

C J Smith

2

1 reference

8 August 2017

R F Georgiou

3

1 reference

8 August 2017

A Vail

4

1 reference

8 August 2017

S J Hopkins

5

1 reference

8 August 2017

N J Rothwell

6

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8 August 2017

Acute Stroke Investigators

8

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8 August 2017

language of work or name

English

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publication date

1 October 2005

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Journal of Neurology, Neurosurgery and Psychiatry

8 August 2017

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8 August 2017

76

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8 August 2017

10

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8 August 2017

1366-1372

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Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

8 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Human cellular inflammation in the pathology of acute cerebral ischaemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Inflammation and infections as risk factors for ischemic stroke

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

FUNCTIONAL EVALUATION: THE BARTHEL INDEX

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

The balance between IL-1 and IL-1Ra in disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Ischemic penumbra: evidence from functional imaging in man.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Acute inflammatory reaction following experimental intracerebral hemorrhage in rat.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Potential mechanisms of interleukin-1 involvement in cerebral ischaemia.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Does the National Institutes of Health Stroke Scale favor left hemisphere strokes? NINDS t-PA Stroke Study Group

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Dissociation between the effects of interleukin-1 on excitotoxic brain damage and body temperature in the rat.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

The medical dictionary for regulatory activities (MedDRA).

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Peripheral white blood cell count in cerebral ischemic infarction.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Interobserver agreement for the assessment of handicap in stroke patients.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Classification and natural history of clinically identifiable subtypes of cerebral infarction

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Reliability of a semi-automated technique of cerebral infarct volume measurement with CT.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Reversible ischemia around intracerebral hemorrhage: a single-photon emission computerized tomography study.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1739363

Medical Complications After Stroke

26 September 2018

1 reference

12 December 2020

Heterogeneity of stroke pathophysiology and neuroprotective clinical trial design

1 reference

12 December 2020

Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled multicenter trial

1 reference

12 December 2020

Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier

1 reference

12 December 2020

The interleukin-1 receptor antagonist (rhIL-1ra) protects against cerebral infarction in a rat model of hypoxia-ischemia

1 reference

12 December 2020

Interleukin-6 and interleukin-1 receptor antagonist in acute stroke

1 reference

12 December 2020

Kidney as a major clearance organ for recombinant human interleukin-1 receptor antagonist

1 reference

12 December 2020

Identifiers

DOI

10.1136/JNNP.2004.054882

1 reference

8 August 2017

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8 August 2017

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