Combination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates. (Q35527105)

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scientific article published on 26 February 2014

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English	Combination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates.	scientific article published on 26 February 2014

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17 March 2020

Combination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates (English)

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Roberta Zappasodi

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Jedd D. Wolchok

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Taha Merghoub

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17 March 2020

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Francesca Avogadri

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Arvin Yang

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Nicole Malandro

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17 March 2020

Daniel Hirschhorn-Cymerman

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Shakuntala Tiwari

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Maureen F Maughan

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Robert Olmsted

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26 February 2014

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17 March 2020

Cancer Immunology Research

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17 March 2020

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17 March 2020

448-458

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17 March 2020

Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer

1 reference

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Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

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27 July 2018

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

1 reference

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1 reference

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Nivolumab plus ipilimumab in advanced melanoma

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Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors.

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PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis

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27 July 2018

Alphavirus Replicon Particles Expressing TRP-2 Provide Potent Therapeutic Effect on Melanoma through Activation of Humoral and Cellular Immunity

1 reference

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An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer

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27 July 2018

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

1 reference

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27 July 2018

Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation

1 reference

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27 July 2018

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

1 reference

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27 July 2018

CD8+ T cell concentration determines their efficiency in killing cognate antigen-expressing syngeneic mammalian cells in vitro and in mouse tissues

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27 July 2018

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

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27 July 2018

PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells

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Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma

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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

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1 reference

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12 December 2020

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10.1158/2326-6066.CIR-13-0220

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17 March 2020

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17 March 2020

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