Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use. (Q35533604)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733584%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use (English)

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1 March 2020

7

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1 March 2020

author name string

Marilyn J Telen

1

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1 March 2020

Ted Wun

2

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1 March 2020

Timothy L McCavit

3

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1 March 2020

Laura M De Castro

4

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1 March 2020

Lakshmanan Krishnamurti

5

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1 March 2020

Sophie Lanzkron

6

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1 March 2020

Wally R Smith

8

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1 March 2020

Seungshin Rhee

9

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1 March 2020

John L Magnani

10

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1 March 2020

Helen Thackray

11

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1 March 2020

language of work or name

English

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publication date

2 March 2015

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1 March 2020

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1 March 2020

volume

125

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issue

17

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1 March 2020

page(s)

2656-2664

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Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

1 March 2020

cites work

1 reference

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Identification of the Ca²⁺ entry pathway involved in deoxygenation-induced phosphatidylserine exposure in red blood cells from patients with sickle cell disease

27 July 2018

1 reference

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Refining the value of secretory phospholipase A2 as a predictor of acute chest syndrome in sickle cell disease: results of a feasibility study (PROACTIVE)

27 July 2018

1 reference

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Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium

27 July 2018

1 reference

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Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial

27 July 2018

1 reference

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GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

27 July 2018

1 reference

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Acute care utilization and rehospitalizations for sickle cell disease

27 July 2018

1 reference

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The inherited diseases of hemoglobin are an emerging global health burden

27 July 2018

1 reference

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Intercellular adhesion molecule-4 and CD36 are implicated in the abnormal adhesiveness of sickle cell SAD mouse erythrocytes to endothelium

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

Multi-modal intervention and prospective implementation of standardized sickle cell pain admission orders reduces 30-day readmission rate

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

Risk factors for hospital readmission within 30 days: a new quality measure for children with sickle cell disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

Hospitalization rates and costs of care of patients with sickle-cell anemia in the state of Maryland in the era of hydroxyurea.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion

27 July 2018

1 reference

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Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

Sickle cell vaso-occlusion: multistep and multicellular paradigm

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease: A randomized controlled trial

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin.

27 July 2018

1 reference

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Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408290

Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates

26 September 2018

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The cost of health care for children and adults with sickle cell disease

26 September 2018

1 reference

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Mechanism of CD47-induced alpha4beta1 integrin activation and adhesion in sickle reticulocytes

26 September 2018

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Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group

26 September 2018

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12 December 2020

Integrin-associated protein is an adhesion receptor on sickle red blood cells for immobilized thrombospondin

1 reference

12 December 2020

Hospital readmission for adult acute sickle cell painful episodes: frequency, etiology, and prognostic significance

1 reference

12 December 2020

Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial

1 reference

12 December 2020

Clinically significant differences in the visual analog pain scale in acute vasoocclusive sickle cell crisis

1 reference

12 December 2020

Population estimates of sickle cell disease in the U.S.

1 reference

12 December 2020

10.1182/BLOOD-2014-06-583351

Identifiers

DOI

1 reference

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1 March 2020

1 reference

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1 March 2020

PubMed publication ID

25733584

1 reference