Phase I studies of sirolimus alone or in combination with pharmacokinetic modulators in advanced cancer patients (Q35542196)

8 August 2017

title

Phase I studies of sirolimus alone or in combination with pharmacokinetic modulators in advanced cancer patients (English)

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8 August 2017

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16

Mark J Ratain

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8 August 2017

1

Ezra E W Cohen

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8 August 2017

Kehua Wu

2

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8 August 2017

Christine Hartford

3

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8 August 2017

Masha Kocherginsky

4

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8 August 2017

Kimberly Napoli Eaton

5

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8 August 2017

Yuanyuan Zha

6

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8 August 2017

Anitha Nallari

7

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8 August 2017

Michael L Maitland

8

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8 August 2017

Kammi Fox-Kay

9

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8 August 2017

Kristin Moshier

10

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8 August 2017

Larry House

11

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8 August 2017

Jacqueline Ramirez

12

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8 August 2017

Samir D Undevia

13

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8 August 2017

Gini F Fleming

14

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8 August 2017

Thomas F Gajewski

15

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8 August 2017

language of work or name

English

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publication date

7 August 2012

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8 August 2017

published in

Clinical Cancer Research

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8 August 2017

volume

18

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8 August 2017

issue

17

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8 August 2017

page(s)

4785-4793

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Two drug interaction studies of sirolimus in combination with sorafenib or sunitinib in patients with advanced malignancies

8 August 2017

cites work

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27 July 2018

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Inconsistent Labeling of Food Effect for Oral Agents across Therapeutic Areas: Differences between Oncology and Non-Oncology Products

27 July 2018

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Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy.

27 July 2018

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Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats

27 July 2018

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Intravenous morphine titration in immediate postoperative pain management: population kinetic-pharmacodynamic and logistic regression analysis

27 July 2018

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Pharmacodynamic-guided modified continuous reassessment method-based, dose-finding study of rapamycin in adult patients with solid tumors

27 July 2018

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27 July 2018

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Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors

27 July 2018

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Identifying optimal biologic doses of everolimus (RAD001) in patients with cancer based on the modeling of preclinical and clinical pharmacokinetic and pharmacodynamic data

27 July 2018

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Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma

27 July 2018

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27 July 2018

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Clinical pharmacokinetics of sirolimus

27 July 2018

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Regulation of translation initiation by FRAP/mTOR

27 July 2018

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A practical guide to the analysis of sirolimus using high-performance liquid chromatography with ultraviolet detection

27 July 2018

1 reference

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Interchangeability and predictive performance of empirical tolerance models

27 July 2018

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Grapefruit juice-drug interactions

27 July 2018

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

27 July 2018

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Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

27 July 2018

1 reference

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Relationship between time of intake of grapefruit juice and its effect on pharmacokinetics and pharmacodynamics of felodipine in healthy subjects

27 July 2018

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Grapefruit juice and drugs. How significant is the interaction?

27 July 2018

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Human brain tumor xenografts in nude mice as a chemotherapy model.

27 July 2018

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A pilot study of low-dose zidovudine in human immunodeficiency virus infection

27 July 2018

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Molecular cloning and overexpression of the human FK506-binding protein FKBP

27 July 2018

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Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin

27 July 2018

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Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.

27 July 2018

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Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer

26 September 2018

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Sirolimus for Kaposi's sarcoma in renal-transplant recipients

26 September 2018

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mTOR as a target for cancer therapy.

26 September 2018

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

26 September 2018

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From beach to bedside: history of the development of sirolimus

26 September 2018

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Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus

26 September 2018

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Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation.

26 September 2018

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Absorption and intestinal metabolism of SDZ-RAD and rapamycin in rats

26 September 2018

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12 December 2020

Activity of rapamycin (AY-22,989) against transplanted tumors

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12 December 2020

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Erythromycin-felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice*

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Identifiers

DOI

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8 August 2017

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8 August 2017

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