Hot-spot mutants of p53 core domain evince characteristic local structural changes. (Q35549859)

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10 December 2019

title

Hot-spot mutants of p53 core domain evince characteristic local structural changes (English)

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10 December 2019

1

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10 December 2019

author name string

B S DeDecker

2

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10 December 2019

S M Freund

3

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10 December 2019

M R Proctor

4

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10 December 2019

M Bycroft

5

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10 December 2019

A R Fersht

6

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10 December 2019

language of work or name

English

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publication date

1 July 1999

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Proceedings of the National Academy of Sciences of the United States of America

10 December 2019

published in

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10 December 2019

volume

96

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10 December 2019

page(s)

8438-8442

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10 December 2019

issue

15

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Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay.

10 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

Thermodynamic stability of wild-type and mutant p53 core domain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

Conformational changes in p53 analysed using new antibodies to the core DNA binding domain of the protein.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

p53 mutations in human cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

p53 domains: identification and characterization of two autonomous DNA-binding regions.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17534

A Suite of Triple Resonance NMR Experiments for the Backbone Assignment of 15N, 13C, 2H Labeled Proteins with High Sensitivity

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.15.8438

Amino-acid-type-selective triple-resonance experiments

21 January 2018

1 reference

12 December 2020

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

1 reference

12 December 2020

Mutations in p53 produce a common conformational effect that can be detected with a panel of monoclonal antibodies directed toward the central part of the p53 protein

1 reference

12 December 2020

Flexibility: the key to p53 function?

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.96.15.8438

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10411893%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

0 references

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10 December 2019

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