Development of the Nitrone‐Based Spin Trap Agent NXY‐059 to Treat Acute Ischemic Stroke (Q35552845)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14530797%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

review article

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title

Development of the nitrone-based spin trap agent NXY-059 to treat acute ischemic stroke (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14530797%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

Development of the Nitrone‐Based Spin Trap Agent NXY‐059 to Treat Acute Ischemic Stroke (English)

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https://api.crossref.org/works/10.1111/J.1527-3458.2003.TB00252.X

18 March 2024

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https://api.crossref.org/works/10.1111/J.1527-3458.2003.TB00252.X

18 March 2024

author name string

Paul A. Lapchak

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14530797

18 March 2024

Dalia M. Araujo

series ordinal

2

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18 March 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14530797

18 March 2024

publication date

1 January 2003

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full work available at URL

19 December 2019

https://europepmc.org/articles/pmc6741678?pdf=render

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Portable Document Format

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14530797

https://europepmc.org/articles/PMC6741678

18 March 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14530797

https://europepmc.org/articles/PMC6741678?pdf=render

18 March 2024

file format

Portable Document Format

online access status

open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14530797

https://doi.org/10.1111/j.1527-3458.2003.tb00252.x

18 March 2024

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14530797

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1527-3458.2003.tb00252.x

18 March 2024

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https://api.crossref.org/works/10.1111/J.1527-3458.2003.TB00252.X

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1527-3458.2003.tb00252.x

18 March 2024

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CNS Neuroscience & Therapeutics

18 March 2024

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14530797%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

volume

9

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19 December 2019

page(s)

253-262

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19 December 2019

issue

3

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Expression of cytokines and activation of transcription factors in lipopolysaccharide-administered rats and their inhibition by phenyl N-tert-butylnitrone (PBN)

19 December 2019

cites work

1 reference

12 December 2020

Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat.

1 reference

12 December 2020

Phenyl-N-tert-butylnitrone demonstrates broad-spectrum inhibition of apoptosis-associated gene expression in endotoxin-treated rats

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12 December 2020

Diagnosis and treatment of ischemic stroke

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12 December 2020

Free radical spin traps as adjuncts for the prevention and treatment of disease

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12 December 2020

Hemorrhagic transformation in acute ischemic stroke. The MAST-E study. MAST-E Group.

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12 December 2020

Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat.

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12 December 2020

Pathobiology of ischaemic stroke: an integrated view

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12 December 2020

Increased oxidative stress brought on by pro-inflammatory cytokines in neurodegenerative processes and the protective role of nitrone-based free radical traps

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12 December 2020

Antioxidants, oxidative stress, and degenerative neurological disorders

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12 December 2020

Neuroprotective effect of alpha-phenyl-N-tert-butylnitrone in gerbil hippocampus is mediated by the mitogen-activated protein kinase pathway and heat shock proteins

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12 December 2020

Atypical effect of some spin trapping agents: reversible inhibition of acetylcholinesterase

1 reference

12 December 2020

Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats

1 reference

12 December 2020

Neuroprotection by 2-h postischemia administration of two free radical scavengers, alpha-phenyl-n-tert-butyl-nitrone (PBN) and N-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN), in rats subjected to focal embolic cerebral ischemia

1 reference

12 December 2020

NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species

1 reference

12 December 2020

Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke

1 reference

12 December 2020

Diagnostic and therapeutic applications of azulenyl nitrone spin traps

1 reference

12 December 2020

Pharmacologic properties of phenyl N-tert-butylnitrone

1 reference

12 December 2020

Tolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute stroke

1 reference

12 December 2020

Paradoxical increase in neuronal DNA fragmentation after neuroprotective free radical scavenger treatment in experimental traumatic brain injury

1 reference

12 December 2020

Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059.

1 reference

12 December 2020

NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat.

1 reference

12 December 2020

Reducing bleeding complications after thrombolytic therapy for stroke: clinical potential of metalloproteinase inhibitors and spin trap agents

1 reference

12 December 2020

Free radical spin trap alpha-phenyl-N-tert-butyl-nitron inhibits caspase-3 activation and reduces brain damage following a severe forebrain ischemic injury.

1 reference

12 December 2020

Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

1 reference

12 December 2020

Hemorrhagic transformation following ischemic stroke: significance, causes, and relationship to therapy and treatment

1 reference

12 December 2020

Tremor and dopamine agonists

1 reference

12 December 2020

Effect of NXY-059 on secondary mitochondrial dysfunction after transient focal ischemia; comparison with cyclosporin A.

1 reference

12 December 2020

Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator

1 reference

12 December 2020

Effects of the spin trap agent disodium- [tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) on intracerebral hemorrhage in a rabbit Large clot embolic stroke model: combination studies with tissue plasminogen activator

1 reference

12 December 2020

Microplasmin: a novel thrombolytic that improves behavioral outcome after embolic strokes in rabbits

1 reference

12 December 2020

Pharmacokinetics in renally impaired subjects of NXY-059, a nitrone-based, free-radical trapping agent developed for the treatment of acute stroke

1 reference

12 December 2020

Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective

1 reference

12 December 2020

In vitro blood-brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions

1 reference

12 December 2020

Development of thrombolytic therapy for stroke: a perspective

1 reference

12 December 2020

Tolerability of NXY-059 at higher target concentrations in patients with acute stroke

1 reference

12 December 2020

Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons

1 reference

12 December 2020

Excretion, metabolism and tissue distribution of a spin trapping agent, alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats

1 reference

12 December 2020

Risk-benefit of thrombolysis.

1 reference

12 December 2020

New variant of human tissue plasminogen activator (TPA) with enhanced efficacy and lower incidence of bleeding compared with recombinant human TPA

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12 December 2020

Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap

1 reference

12 December 2020

Neurophysiological consequences of nitroxide antioxidants

1 reference

12 December 2020

N-tert-butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia

1 reference

12 December 2020

Nitrone spin trap lipophilicity as a determinant for inhibition of low density lipoprotein oxidation and activation of interleukin-1 beta release from human monocytes

1 reference

12 December 2020

Nitric oxide formation during light-induced decomposition of phenyl N-tert-butylnitrone

1 reference

12 December 2020

Nitrone spin-traps block calcium channels and induce pulmonary artery relaxation independent of free radicals.

1 reference

12 December 2020

Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis

1 reference

12 December 2020

Characterization of the radical trapping activity of a novel series of cyclic nitrone spin traps

1 reference

12 December 2020

Mechanisms of secondary brain injury

1 reference

12 December 2020

Nitrone-based free radical traps as neuroprotective agents in cerebral ischaemia and other pathologies.

1 reference

12 December 2020

Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat.

1 reference

12 December 2020

Systematic review of evidence on thrombolytic therapy for acute ischaemic stroke

1 reference

12 December 2020

tPA-associated reperfusion after acute stroke demonstrated by SPECT

1 reference

12 December 2020

Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of alpha-phenyl-N-tert-butyl nitrone.

1 reference

12 December 2020

PBN spin trapping of free radicals in the reperfusion-injured heart. Limitations for pharmacological investigations

1 reference

12 December 2020

Interaction of alpha-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site.

1 reference

12 December 2020

Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon.

1 reference

12 December 2020

Free radicals as mediators of neuronal injury.

1 reference

12 December 2020

In vitro and in vivo effects of genistein on murine alveolar macrophage TNF alpha production

series ordinal

12

1 reference

https://api.crossref.org/works/10.1111/J.1527-3458.2003.TB00252.X

18 March 2024

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14530797%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14530797%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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