Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia (Q35553586)

8 August 2017

title

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia (English)

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8 August 2017

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Benjamin Mizukawa

1

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8 August 2017

Junping Wei

2

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8 August 2017

Mahesh Shrestha

3

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8 August 2017

Mark Wunderlich

4

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8 August 2017

Fu-Sheng Chou

5

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8 August 2017

Andrea Griesinger

6

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8 August 2017

Chad E Harris

7

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8 August 2017

Ashish R Kumar

8

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8 August 2017

Yi Zheng

9

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8 August 2017

David A Williams

10

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8 August 2017

James C Mulloy

11

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8 August 2017

language of work or name

English

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publication date

22 September 2011

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8 August 2017

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8 August 2017

volume

118

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8 August 2017

issue

19

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8 August 2017

page(s)

5235-5245

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The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity

8 August 2017

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A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

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12 July 2018

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12 July 2018

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12 July 2018

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

12 July 2018

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Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4+CD8+ immature thymocyte line

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

12 July 2018

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Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage

12 July 2018

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Rho and Rac take center stage

12 July 2018

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12 July 2018

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Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

12 July 2018

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12 July 2018

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Characterization of RAC3, a novel member of the Rho family

12 July 2018

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An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

12 July 2018

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Systems biology and combination therapy in the quest for clinical efficacy.

12 July 2018

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Oncogenic Vav1 induces Rac-dependent apoptosis via inhibition of Bcl-2 family proteins and collaborates with p53 deficiency to promote hematopoietic progenitor cell proliferation

26 September 2018

1 reference

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Gene expression profiling of pediatric acute myelogenous leukemia

26 September 2018

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FLT3 mutations are associated with other molecular lesions in AML.

26 September 2018

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Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

26 September 2018

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Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification

26 September 2018

1 reference

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Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.

26 September 2018

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Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors

26 September 2018

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12 December 2020

Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases

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12 December 2020

Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization

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12 December 2020

Pediatric acute myeloid leukemia: international progress and future directions

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12 December 2020

Expansion of normal and leukemic human hematopoietic stem/progenitor cells requires rac-mediated interaction with stromal cells

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12 December 2020

Acute myeloid leukemia

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12 December 2020

10.1182/BLOOD-2011-04-351817

Identifiers

DOI

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8 August 2017

1 reference

8 August 2017

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