DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling (Q35557645)

8 August 2017

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title

DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling (English)

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8 August 2017

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Bernd Kaina

1

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PubMed ID

14555233

8 August 2017

language of work or name

English

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publication date

1 October 2003

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8 August 2017

Biochemical Pharmacology

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8 August 2017

66

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8 August 2017

8

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8 August 2017

1547-1554

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Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

8 August 2017

1 reference

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Mismatch binding proteins and tolerance to alkylating agents in human cells

7 January 2021

1 reference

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O6-alkylguanine DNA lesions trigger apoptosis

7 January 2021

1 reference

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Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

7 January 2021

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Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting.

7 January 2021

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Specific binding of human MSH2.MSH6 mismatch-repair protein heterodimers to DNA incorporating thymine- or uracil-containing UV light photoproducts opposite mismatched bases.

7 January 2021

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Requirement of mammalian DNA polymerase-beta in base-excision repair.

7 January 2021

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Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation

7 January 2021

1 reference

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Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells

7 January 2021

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Cisplatin-induced apoptosis in 43-3B and 27-1 cells defective in nucleotide excision repair

7 January 2021

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Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug beta-D-glucosyl-ifosfamide mustard

7 January 2021

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Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches

7 January 2021

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Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation

7 January 2021

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Cloning and functional analysis of cDNA encoding the hamster Bcl-2 protein

7 January 2021

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Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.

7 January 2021

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Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8.

7 January 2021

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Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir

7 January 2021

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Chromosomal aberrations induced by restriction endonucleases

7 January 2021

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DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts

7 January 2021

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Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-Fos, p53 or both

7 January 2021

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p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes

7 January 2021

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A role for p53 in base excision repair.

7 January 2021

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Cancer. p53, guardian of the genome

7 January 2021

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Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis

7 January 2021

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Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling

7 January 2021

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Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53

7 January 2021

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c-Fos is involved in the cellular defence against the genotoxic effect of UV radiation

7 January 2021

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DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

7 January 2021

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Cisplatin induces a persistent activation of JNK that is related to cell death

7 January 2021

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Critical steps in alkylation-induced aberration formation

7 January 2021

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Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins

7 January 2021

1 reference

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Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.

7 January 2021

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10.1016/S0006-2952(03)00510-0

7 January 2021

Identifiers

DOI

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8 August 2017

1 reference

PubMed ID

14555233