Tumor specific activation of PKR as a non-toxic modality of cancer treatment (Q35561619)

8 August 2017

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title

Tumor specific activation of PKR as a non-toxic modality of cancer treatment (English)

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8 August 2017

Alexei Shir

1

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PubMed ID

14563126

8 August 2017

Inbar Friedrich

series ordinal

2

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PubMed ID

14563126

8 August 2017

Alexander Levitzki

series ordinal

3

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8 August 2017

1 August 2003

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Seminars in Cancer Biology

8 August 2017

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8 August 2017

13

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8 August 2017

4

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8 August 2017

309-314

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Inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded RNA and oxidized glutathione: indirect mode of action on polypeptide chain initiation

8 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Phosphorylation of initiation factor elF-2 and the control of reticulocyte protein synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Regulation of protein synthesis: Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Characterization of double-stranded-RNA-activated kinase that phosphorylates alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha) in reticulocyte lysates

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Specific phosphorylation in vitro of a protein associated with ribosomes of interferon-treated mouse L cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Mechanism of interferon action: Phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

The double stranded RNA-activated protein kinase induced by interferon: dsRNA-PK.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Regulation of eukaryotic protein synthesis by protein kinases that phosphorylate initiation factor eIF-2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Initiation of protein synthesis in eukaryotic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

PKR, apoptosis and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Interactions between double-stranded RNA regulators and the protein kinase DAI

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Low frequency of rearrangements of the homeobox gene HOXA9/t(7;11) in adult acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

A rare chimeric TLS/FUS-CHOP transcript in a patient with multiple liposarcomas: a case report

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts).

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Novel breakpoints of the EWS gene and the WT1 gene in a desmoplastic small round cell tumor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

EWS-FLI1 fusion transcripts identified in patients with typical neuroblastoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Novel formation and amplification of the PAX7-FKHR fusion gene in a case of alveolar rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Involvement of the ALL-1 gene in a solid tumor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Aberrant splicing of the TSG101 tumor suppressor gene in human breast and ovarian cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Inhibition of glioma growth by tumor-specific activation of double-stranded RNA-dependent protein kinase PKR.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

Protection of translation initiation factor eIF2 phosphorylation correlates with eIF2-associated glycoprotein p67 levels and requires the lysine-rich domain I of p67.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2803%2900045-2

7 January 2021

10.1016/S1044-579X(03)00045-2

Identifiers

DOI

1 reference

8 August 2017

1 reference

PubMed ID

14563126