Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2. (Q35564020)

8 August 2017

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2. (English)

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8 August 2017

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Andrea D Basso

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8 August 2017

David B Solit

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2

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8 August 2017

Pamela N Munster

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3

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8 August 2017

Neal Rosen

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4

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8 August 2017

language of work or name

English

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publication date

1 February 2002

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8 August 2017

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8 August 2017

21

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1159-1166

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8 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205184

8 August 2017

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cites work

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Modulation of Akt kinase activity by binding to Hsp90

12 July 2018

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An immunotherapeutic approach to treatment of breast cancer: focus on trastuzumab plus paclitaxel. Breast Cancer Medicine Service

12 July 2018

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12 July 2018

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The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network

12 July 2018

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Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

12 July 2018

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Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways

12 July 2018

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Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

12 July 2018

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Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers

12 July 2018

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

12 July 2018

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

12 July 2018

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Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment

12 July 2018

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ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.

12 July 2018

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The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors

12 July 2018

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Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

12 July 2018

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

12 July 2018

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Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

12 July 2018

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Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus

12 July 2018

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

12 July 2018

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

12 July 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

12 July 2018

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The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

12 July 2018

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Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

12 July 2018

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Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

12 July 2018

1 reference

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Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

12 July 2018

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Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells

12 July 2018

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Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

12 July 2018

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221005

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

12 July 2018

1 reference

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Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3

12 July 2018

1 reference

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

12 July 2018

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221005

Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221005

Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221005

Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221005

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205184

Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11850835

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sporadic amplification of the HER2/neu protooncogene in adenocarcinomas of various tissues

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11850835

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11850835

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1205184

1 reference

8 August 2017

1 reference

8 August 2017

1 reference