Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture (Q35570793)

8 August 2017

title

Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture (English)

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8 August 2017

author name string

Stephen C Pflugfelder

series ordinal

1

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8 August 2017

language of work or name

English

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publication date

22 October 2011

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American Journal of Ophthalmology

8 August 2017

published in

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8 August 2017

volume

152

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8 August 2017

issue

6

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8 August 2017

page(s)

900-909.e1

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Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-γ

8 August 2017

cites work

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Entrapment of conjunctival goblet cells by desiccation-induced cornification

12 July 2018

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Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13.

12 July 2018

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Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea.

12 July 2018

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Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjögren's syndrome

12 July 2018

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Noninvasive assessment of tear stability with the tear stability analysis system in tear dysfunction patients

12 July 2018

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c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium.

12 July 2018

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Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease

12 July 2018

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Cold-sensitive corneal afferents respond to a variety of ocular stimuli central to tear production: implications for dry eye disease

12 July 2018

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Membrane-tethered mucins have multiple functions on the ocular surface.

12 July 2018

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Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress

12 July 2018

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Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy

12 July 2018

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Association between high tear epidermal growth factor levels and corneal subepithelial fibrosis in dry eye conditions

12 July 2018

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Corneal epithelial opacity in dysfunctional tear syndrome

12 July 2018

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Prevalence of dry eye disease among US men: estimates from the Physicians' Health Studies

12 July 2018

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Investigation of the corneal filament in filamentary keratitis

12 July 2018

1 reference

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Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome

12 July 2018

1 reference

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IL-17 disrupts corneal barrier following desiccating stress.

12 July 2018

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Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients.

12 July 2018

1 reference

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Corneal pain without stain: is it real?

12 July 2018

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Tear cytokine profiles in dysfunctional tear syndrome.

12 July 2018

1 reference

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Contributions of evaporation and other mechanisms to tear film thinning and break-up

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Cyclosporin A inhibits the production of IL-17 by memory Th17 cells from healthy individuals and patients with rheumatoid arthritis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Topical omega-3 and omega-6 fatty acids for treatment of dry eye.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Effect of blinking on tear dynamics

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Assay of mucins in human tear fluid.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Human tear fluid protects against Pseudomonas aeruginosa keratitis in a murine experimental model.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Dysfunctional tear syndrome: a Delphi approach to treatment recommendations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Fluid-ventilated, gas-permeable scleral contact lens is an effective option for managing severe ocular surface disease and many corneal disorders that would otherwise require penetrating keratoplasty

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Tear film stability analysis system: introducing a new application for videokeratography

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Proteomic analysis of human tears: defensin expression after ocular surface surgery.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Prevalence of dry eye syndrome among US women

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Abnormal protein profiles in tears with dry eye syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Management of filamentary keratitis associated with aqueous-deficient dry eye.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Towards a closed eye model of the pre-ocular tear layer.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Results of a population-based questionnaire on the symptoms and lifestyles associated with dry eye.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Vasoactive intestinal polypeptide (VIP) innervation of the human eyelid glands

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Antimicrobial defensin peptides of the human ocular surface

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Histochemical study on rat tear film and ocular surface epithelial cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

The epidemiology of dry eye in Melbourne, Australia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Prevalence of dry eye among the elderly

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Ocular rosacea: patient characteristics and follow-up.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

The effects of age, gender, and fluid dynamics on the concentration of tear film epidermal growth factor.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Transforming growth factor beta-1 and beta-2 in human tear fluid

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Regulation of tear secretion.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

The histopathology of filamentary keratitis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Demonstration of the mucous layer of the tear film by electron microscopy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

The relation of functional visual acuity measurement methodology to tear functions and ocular surface status

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

An objective approach to dry eye disease severity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

A mass and solute balance model for tear volume and osmolarity in the normal and the dry eye.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

In vivo characterization of doxycycline effects on tear metalloproteinases in patients with chronic blepharitis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Amelioration of murine dry eye disease by topical antagonist to chemokine receptor 2.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Treatment of superior limbic keratoconjunctivitis with a large-diameter contact lens and Botulium Toxin A.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Modulation of integrin alpha4beta1 (VLA-4) in dry eye disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Prevalence of dry eye disease among Japanese visual display terminal users

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Does orally administered doxycycline reach the tear film?

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Conjunctival and corneal pneumatic sensitivity is associated with signs and symptoms of ocular dryness

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Increased evaporative rates in laboratory testing conditions simulating airplane cabin relative humidity: an important factor for dry eye syndrome.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Effect of experimental dry eye on tear sodium concentration in the mouse.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

The application of a new continuous functional visual acuity measurement system in dry eye syndromes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

The effect of autologous serum eyedrops in the treatment of severe dry eye disease: a prospective randomized case-control study

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Morphology of corneal nerves and corneal sensation in dry eye: a preliminary study

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Incidence of dry eye in an older population

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Successful management of three consecutive cases of recurrent corneal erosion with botulinum toxin injections.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Substance P in human tears

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Utility assessment among patients with dry eye disease.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Assessing the severity of keratitis sicca with videokeratoscopic indices

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Presence of nerves and their receptors in mouse and human conjunctival goblet cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Gas-permeable scleral contact lens therapy in ocular surface disease.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Stress-activated protein kinase signaling pathways in dry eye and ocular surface disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Reduced corneal sensitivity in patients with primary Sjögren’s syndrome

24 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223272

Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea

7 December 2018

1 reference

12 December 2020

Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γ

1 reference

12 December 2020

Changes in rat corneal matrix metalloproteinases and serine proteinases under vitamin A deficiency

1 reference

12 December 2020

The concentration of lysozyme and secretory IgA in tears from healthy persons with and without contact lens use

1 reference

12 December 2020

An in vivo confocal masked study on corneal epithelium and subbasal nerves in patients with dry eye

1 reference

12 December 2020

Structure and composition of rat precorneal tear film. A study by an in vivo cryofixation

1 reference

12 December 2020

Corneal Infection in Mucosal Scarring Disorders and SjöUgren's Syndrome

1 reference

12 December 2020

Identification, origins and the diurnal role of the principal serine protease inhibitors in human tear fluid.

1 reference

12 December 2020

Smoking associated with damage to the lipid layer of the ocular surface

1 reference

12 December 2020

Tear film osmolarity: determination of a referent for dry eye diagnosis

1 reference

12 December 2020

Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant

1 reference

12 December 2020

Changes in the diurnal pattern of the distribution of gelatinases and associated proteins in normal and pathological tear fluids: evidence that the PMN cell is a major source of MMP activity in tear fluid

1 reference

12 December 2020

Optical and visual impact of tear break-up in human eyes

1 reference

12 December 2020

Effect of artificial tears on corneal surface regularity, contrast sensitivity, and glare disability in dry eyes

1 reference

12 December 2020

Physical chemistry of the normal and disordered tear film

1 reference

12 December 2020

On the ocular refractive components: the Reykjavik Eye Study

1 reference

12 December 2020

Dynamic changes in the tear film in dry eyes

1 reference

12 December 2020

Cytokine and chemokine levels in tears from healthy subjects

1 reference

12 December 2020

The concentration of lactoferrin in tears of normals and of diabetics

1 reference

12 December 2020

Prevalence of and risk factors for dry eye syndrome

1 reference

12 December 2020

The effects of experimental tear film removal on corneal surface regularity and barrier function

1 reference

12 December 2020

[Microbial keratitis: a 4 year study of risk factors and traditional/complementary medicine in Oman]

1 reference

12 December 2020

Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways

1 reference

12 December 2020

The pathology of dry eye: the interaction between the ocular surface and lacrimal glands

1 reference

12 December 2020

Serial measurements of higher-order aberrations after blinking in patients with dry eye

1 reference

12 December 2020

Effects of Sequential Artificial Tear and Cyclosporine Emulsion Therapy on Conjunctival Goblet Cell Density and Transforming Growth Factor-β2 Production

1 reference

12 December 2020

Contrast sensitivity and disability glare in patients with dry eye

1 reference

12 December 2020

Screening for dry eye with newly developed ocular surface thermographer

1 reference

12 December 2020

Low spatial-contrast sensitivity in dry eyes

1 reference

12 December 2020

10.1016/J.AJO.2011.08.023

Identifiers

DOI

1 reference

8 August 2017

1 reference

8 August 2017

1 reference