The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease. (Q35571071)

From Wikidata

Jump to navigation Jump to search

scientific article published on 25 September 2011

Language	Label	Description	Also known as
English	The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease.	scientific article published on 25 September 2011

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

sickle-cell disease

0 references

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

author name string

Tohru Ikuta

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Adekunle D Adekile

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Diana R Gutsaeva

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

James B Parkerson

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Shobha D Yerigenahally

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Betsy Clair

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Abdullah Kutlar

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

C Alvin Head

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

publication date

25 September 2011

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Blood Cells, Molecules and Diseases

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

47

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

235-242

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

cAMP differentially regulates gamma-globin gene expression in erythroleukemic cells and primary erythroblasts through c-Myb expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Nitric oxide inhibits rhinovirus-induced granulocyte macrophage colony-stimulating factor production in bronchial epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Mechanism for fetal globin gene expression: role of the soluble guanylate cyclase-cGMP-dependent protein kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Management of sickle cell disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Signals for activation of the GM-CSF promoter and enhancer in T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Hydroxyurea and sickle cell anemia. Clinical utility of a myelosuppressive "switching" agent. The Multicenter Study of Hydroxyurea in Sickle Cell Anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Cyclic nucleotide phosphodiesterases and vascular smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Secretion of the eosinophil‐active cytokines interleukin‐5, granulocyte/macrophage colonystimulating factor and interleukin‐3 by bronchoalveolar lavage CD4+ and CD8+ T cell lines in atopics asthmatics, and atopic and nonatopic controls

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Arabinosylcytosine Induces Fetal Hemoglobin in Baboons by Perturbing Erythroid Cell Differentiation Kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

An unusual pattern of neutrophil kinetics in sickle cell anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Granulocyte-macrophage colony-stimulating factor reactivates fetal hemoglobin synthesis in erythroblast clones from normal adults.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Mechanism of Hb F stimulation by S-stage compounds. In vitro studies with bone marrow cells exposed to 5-azacytidine, Ara-C, or hydroxyurea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

In vivo protein-DNA interactions at the beta-globin gene locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Mechanism of action of hydroxyurea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

12 July 2018

Expression of the gamma-globin gene is sustained by the cAMP-dependent pathway in beta-thalassaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

Response to hydroxyurea treatment in Iranian transfusion-dependent beta-thalassemia patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

Mortality in sickle cell patients on hydroxyurea therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

Negative regulation of gamma-globin gene expression by cyclic AMP-dependent pathway in erythroid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

Increased soluble guanylate cyclase activity in the red blood cells of sickle cell patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

A signaling mechanism for growth-related expression of fetal hemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

Placenta growth factor activates monocytes and correlates with sickle cell disease severity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

Prediction of adverse outcomes in children with sickle cell disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

Dissecting the loci controlling fetal haemoglobin production on chromosomes 11p and 6q by the regressive approach.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

F reticulocyte response in sickle cell anemia treated with recombinant human erythropoietin: a double-blind study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

26 September 2018

Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223356

7 December 2018

Human monocyte-endothelial cell interaction induces synthesis of granulocyte-macrophage colony-stimulating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new high-performance liquid chromatographic procedure to quantitate hemoglobin A1c and other minor hemoglobins in blood of normal, diabetic, and alcoholic individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and analysis of human erythropoietin receptors on a factor-dependent cell line, TF-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxyurea-induced HbF production in anemic primates: augmentation by erythropoietin, hematopoietic growth factors, and sodium butyrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating cytokines in sickle cell patients during steady state

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molgramostim to treat SS-sickle cell leg ulcers

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of colony-stimulating factors in synovial fluid: potential clinical value

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat liver-mediated metabolism of hydroxyurea to nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leukocyte numbers correlate with plasma levels of granulocyte-macrophage colony-stimulating factor in sickle cell disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized comparison of G-CSF + GM-CSF vs G-CSF alone for mobilization of peripheral blood stem cells: effects on hematopoietic recovery after high-dose chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo production of nitric oxide in rats after administration of hydroxyurea

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulocytosis causing sickle-cell crisis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in protein-DNA interactions in the gamma-globin gene promoter in response to butyrate therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating cytokines response and the level of erythropoiesis in sickle cell anemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BCMD.2011.08.005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21945571%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q35571071&oldid=1525152907"