Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow. (Q35577829)

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5 March 2020

title

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow (English)

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5 March 2020

3

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author name string

Mandy B Esch

1

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5 March 2020

Jean-Matthieu Prot

2

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5 March 2020

Paula Miller

4

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5 March 2020

Jose Ricardo Llamas-Vidales

5

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5 March 2020

Brian A Naughton

6

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5 March 2020

Dawn R Applegate

7

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Michael L Shuler

8

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publication date

1 May 2015

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5 March 2020

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volume

15

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issue

10

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5 March 2020

page(s)

2269-2277

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Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

5 March 2020

cites work

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Bioreactor technologies to support liver function in vitro.

27 July 2018

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Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro

27 July 2018

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Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes.

27 July 2018

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Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays.

27 July 2018

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Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments

27 July 2018

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Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

27 July 2018

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A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

27 July 2018

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Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

27 July 2018

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Long-term maintenance of human hepatocytes in oxygen-permeable membrane bioreactor

27 July 2018

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Idiosyncratic drug hepatotoxicity

27 July 2018

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Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies

27 July 2018

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Development of a microscale cell culture analog to probe naphthalene toxicity

27 July 2018

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Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor

27 July 2018

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A novel system to study the impact of epithelial barriers on cellular metabolism

27 July 2018

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Perifused monolayer cultures of rat hepatocytes as an improved in vitro system for studies on ureogenesis

27 July 2018

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A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

27 July 2018

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A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

26 September 2018

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A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

26 September 2018

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A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip

26 September 2018

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Study of the crosstalk between hepatocytes and endothelial cells using a novel multicompartmental bioreactor: a comparison between connected cultures and cocultures.

26 September 2018

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A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

26 September 2018

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Perfusion of medium with supplemented growth factors changes metabolic activities and cell morphology of hepatocyte-nonparenchymal cell coculture

26 September 2018

1 reference

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A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: cell viability and tissue-specific functions.

26 September 2018

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Laminar-flow immediate-overlay hepatocyte sandwich perfusion system for drug hepatotoxicity testing

26 September 2018

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12 December 2020

Evaluation of a novel in vitro Caco-2 hepatocyte hybrid system for predicting in vivo oral bioavailability

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12 December 2020

A perifusion system for cultured hepatocytes

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12 December 2020

Effects of shear stress on metabolic function of the co-culture system of hepatocyte/nonparenchymal cells for a bioartificial liver

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12 December 2020

Identifiers

DOI

10.1039/C5LC00237K

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release_kj2jnltcuba65lnd3pyf6nolqy

5 March 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/kj2jnltcuba65lnd3pyf6nolqy

24 November 2022

mapped directly with Wikidata item

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5 March 2020

PubMed publication ID

25857666

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