Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease (Q35594747)

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scientific article published on July 2002

Language	Label	Description	Also known as
English	Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease	scientific article published on July 2002

Statements

scholarly article

1 reference

Europe PubMed Central

9 August 2017

Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease (English)

1 reference

Europe PubMed Central

9 August 2017

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Crohn's disease

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author name string

B R Yacyshyn

1

1 reference

Europe PubMed Central

9 August 2017

W Y Chey

2

1 reference

Europe PubMed Central

9 August 2017

J Goff

3

1 reference

Europe PubMed Central

9 August 2017

B Salzberg

4

1 reference

Europe PubMed Central

9 August 2017

R Baerg

5

1 reference

Europe PubMed Central

9 August 2017

A L Buchman

6

1 reference

Europe PubMed Central

9 August 2017

J Tami

7

1 reference

Europe PubMed Central

9 August 2017

R Yu

8

1 reference

Europe PubMed Central

9 August 2017

E Gibiansky

9

1 reference

Europe PubMed Central

9 August 2017

W R Shanahan

10

1 reference

Europe PubMed Central

9 August 2017

ISIS 2302-CS9 Investigators

11

1 reference

Europe PubMed Central

9 August 2017

language of work or name

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publication date

1 July 2002

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

51

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Europe PubMed Central

9 August 2017

1

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Europe PubMed Central

9 August 2017

30-36

1 reference

Europe PubMed Central

9 August 2017

T-Cell Function and Migration — Two Sides of the Same Coin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Comparative studies of the colonic in situ expression of intercellular adhesion molecules (ICAM-1, -2, and -3), beta2 integrins (LFA-1, Mac-1, and p150,95), and PECAM-1 in ulcerative colitis and Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Properties of cloned and expressed human RNase H1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Regulation of ICAM-1-mediated fibroblast-T cell reciprocal interaction: implications for modulation of gut inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Correlation of toxicity and pharmacokinetic properties of a phosphorothioate oligonucleotide designed to inhibit ICAM-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

The role of tumor necrosis factor in health and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Beta2 integrin/ICAM expression in Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Quantitation of phosphorothioate oligonucleotides in human plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Regulation of adhesion molecule expression by human synovial microvascular endothelial cells in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Enhanced metastatic ability of TNF-alpha-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

12 July 2018

Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

26 September 2018

Changed colonic profile of P-selectin, platelet-endothelial cell adhesion molecule-1 (PECAM-1), intercellular adhesion molecule-1 (ICAM-1), ICAM-2, and ICAM-3 in inflammatory bowel disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

26 September 2018

Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

26 September 2018

Activation of the alternative pathway of complement by a phosphorothioate oligonucleotide: potential mechanism of action.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

26 September 2018

An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

26 September 2018

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773277

15 November 2018

A phase I/II open label study of the safety and efficacy of an anti-ICAM-1 (intercellular adhesion molecule-1; CD54) monoclonal antibody in early rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repeat treatment of rheumatoid arthritis patients with a murine anti-intercellular adhesion molecule 1 monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple-dose pharmacokinetics of a long half-life drug: contributions of mathematical modeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A form of circulating ICAM-1 in human serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased levels of circulating intercellular adhesion molecule 1 in the sera of patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crohn's disease, ulcerative colitis, and normal intestinal lymphocytes express integrins in dissimilar patterns

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cationic lipid is not required for uptake and selective inhibitory activity of ICAM-1 phosphorothioate antisense oligonucleotides in keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocking of heart allograft rejection by intercellular adhesion molecule-1 antisense oligonucleotides alone or in combination with other immunosuppressive modalities

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate for the Treatment of Crohn's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of E-selectin and intercellular adhesion molecule-1 differs between Crohn's disease and ulcerative colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inferring systemic exposure from a pharmacokinetic screen: model-free and model-based approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of costimulatory molecules on peripheral blood monocytes in patients with Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/GUT.51.1.30

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

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