In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model (Q35597017)

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scientific article published on May 2015

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English	In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model	scientific article published on May 2015

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1 March 2020

In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model (English)

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1 March 2020

Lucía Hipólito

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1 March 2020

Amanda K Fakira

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1 March 2020

David Cabañero

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1 March 2020

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Rebecca Blandón

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Susan M Carlton

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1 March 2020

Jose A Morón

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Zara Melyan

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1 May 2015

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1 March 2020

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1 March 2020

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1 March 2020

849-858

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1 March 2020

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Synaptic GluN2A and GluN2B containing NMDA receptors within the superficial dorsal horn activated following primary afferent stimulation

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Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels

1 reference

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Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine.

1 reference

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Synaptic NMDA receptor-dependent Ca²⁺ entry drives membrane potential and Ca²⁺ oscillations in spinal ventral horn neurons.

1 reference

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Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.

1 reference

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Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ

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12 July 2018

Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine.

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12 July 2018

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12 July 2018

Central sensitization: Implications for the diagnosis and treatment of pain

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12 July 2018

Functional interplay between NMDA receptors, SK channels and voltage-gated Ca2+ channels regulates synaptic excitability in the medial prefrontal cortex

1 reference

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12 July 2018

Cellular and Molecular Mechanisms of Pain

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Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation

1 reference

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12 July 2018

Depletion of SK1 channel subunits leads to constitutive insulin secretion

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12 July 2018

Numbers, densities, and colocalization of AMPA- and NMDA-type glutamate receptors at individual synapses in the superficial spinal dorsal horn of rats

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Inflammatory pain-induced signaling events following a conditional deletion of the N-methyl-D-aspartate receptor in spinal cord dorsal horn

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Spinal cord injury induces changes in electrophysiological properties and ion channel expression of reticulospinal neurons in larval lamprey

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12 July 2018

Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways

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12 July 2018

Opposing effects of spinal nerve ligation on calcium-activated potassium currents in axotomized and adjacent mammalian primary afferent neurons.

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12 July 2018

Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.

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12 July 2018

SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines.

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Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain

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Treatment with the NMDA antagonist memantine attenuates nociceptive responses to mechanical stimulation in neuropathic rats

1 reference

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based on heuristic

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NMDA receptor antagonists attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw

1 reference

https://pubmed.ncbi.nlm.nih.gov/25734988

12 December 2020

based on heuristic

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NMDA receptors are important for both mechanical and thermal allodynia from peripheral nerve injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/25734988

12 December 2020

based on heuristic

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The clinically available NMDA receptor antagonist memantine is antinociceptive on rat spinal neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/25734988

12 December 2020

based on heuristic

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Electrophysiologic changes in dorsal root ganglion neurons and behavioral changes in a lumbar radiculopathy model

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https://pubmed.ncbi.nlm.nih.gov/25734988

12 December 2020

based on heuristic

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Effect of systemic N-methyl-D-aspartate receptor antagonist (dextromethorphan) on primary and secondary hyperalgesia in humans

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https://pubmed.ncbi.nlm.nih.gov/25734988

12 December 2020

based on heuristic

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Changes in somatic action potential shape in guinea-pig nociceptive primary afferent neurones during inflammation in vivo

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https://pubmed.ncbi.nlm.nih.gov/25734988

12 December 2020

based on heuristic

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Both Ca2+-permeable and -impermeable AMPA receptors contribute to primary synaptic drive onto rat dorsal horn neurons

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https://pubmed.ncbi.nlm.nih.gov/25734988

12 December 2020

based on heuristic

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10.1097/J.PAIN.0000000000000124

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