A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834 (Q35600249)

25845827

9 August 2017

title

A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834 (English)

1 reference

9 August 2017

3

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8 June 2020

author name string

Jasleen K Sodhi

1

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8 June 2020

Susan Wong

2

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8 June 2020

Lichuan Liu

4

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8 June 2020

S Cyrus Khojasteh

5

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8 June 2020

Cornelis E C A Hop

6

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8 June 2020

John T Barr

7

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8 June 2020

Jeffrey P Jones

8

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8 June 2020

Jason S Halladay

9

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8 June 2020

publication date

6 April 2015

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25845827

Drug Metabolism and Disposition

9 August 2017

published in

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8 June 2020

volume

43

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8 June 2020

issue

6

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8 June 2020

page(s)

908-915

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Inhibition of xanthine oxidase by the aldehyde oxidase inhibitor raloxifene: implications for identifying molybdopterin nitrite reductases

8 June 2020

cites work

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Predicting intrinsic clearance for drugs and drug candidates metabolized by aldehyde oxidase

27 July 2018

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The First Mammalian Aldehyde Oxidase Crystal Structure: INSIGHTS INTO SUBSTRATE SPECIFICITY

27 July 2018

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Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase

27 July 2018

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Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes

27 July 2018

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Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma

27 July 2018

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Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

27 July 2018

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Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals

27 July 2018

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Studies on the mechanism of aldehyde oxidase and xanthine oxidase

27 July 2018

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Drug-metabolizing ability of molybdenum hydroxylases

27 July 2018

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Human liver aldehyde oxidase: differential inhibition of oxidation of charged and uncharged substrates

27 July 2018

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Species variation in hepatic aldehyde oxidase activity

27 July 2018

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Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations

27 July 2018

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Inhibition of human liver aldehyde oxidase: implications for potential drug-drug interactions

26 September 2018

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Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy

26 September 2018

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Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human

26 September 2018

1 reference

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Identification of the cytosolic carboxylesterase catalyzing the 5'-deoxy-5-fluorocytidine formation from capecitabine in human liver

26 September 2018

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Potent inhibition of human liver aldehyde oxidase by raloxifene

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429680

Human liver aldehyde oxidase: inhibition by 239 drugs

26 September 2018

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Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase

26 September 2018

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Characterization of the expression and activity of carboxylesterases 1 and 2 from the beagle dog, cynomolgus monkey, and human

26 September 2018

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12 December 2020

Effect of structural variation on aldehyde oxidase-catalyzed oxidation of zoniporide

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12 December 2020

Irreversible Enzyme Inhibitors. CII. On the Mode of Phenyl Binding of 9-Phenylguanine to Guanine Deaminase and Xanthine Oxidase1-4

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12 December 2020

Studies on the mode of oxidation of pyrazolo(3,4-d)pyrimidine by aldehyde oxidase and xanthine oxidase

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12 December 2020

1-substituted phthalazines as probes of the substrate-binding site of mammalian molybdenum hydroxylases

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12 December 2020

Human xenobiotic metabolizing esterases in liver and blood

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12 December 2020

Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon

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12 December 2020

Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by Human Liver Carboxylesterase

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12 December 2020

Aldehyde oxidase-dependent marked species difference in hepatic metabolism of the sedative-hypnotic, zaleplon, between monkeys and rats

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12 December 2020

Carboxylesterase in the liver and small intestine of experimental animals and human

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12 December 2020

Inter-species variation in the metabolism and inhibition of N-[(2'-dimethylamino)ethyl]acridine-4-carboxamide (DACA) by aldehyde oxidase

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12 December 2020

Identifiers

DOI

10.1124/DMD.114.061804

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25845827%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

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8 June 2020

25845827

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