Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading (Q35601229)

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scientific article published on 30 August 2011

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English	Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading	scientific article published on 30 August 2011

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scholarly article

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11 February 2020

Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading (English)

1 reference

Europe PubMed Central

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11 February 2020

3

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11 February 2020

author name string

Chandrasekhar Kesavan

1

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11 February 2020

Jon E Wergedal

2

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11 February 2020

Subburaman Mohan

4

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11 February 2020

publication date

30 August 2011

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11 February 2020

American Journal of Physiology - Endocrinology and Metabolism

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11 February 2020

301

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11 February 2020

6

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11 February 2020

E1191-7

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11 February 2020

Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression

1 reference

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Ephrin B1 regulates bone marrow stromal cell differentiation and bone formation by influencing TAZ transactivation via complex formation with NHERF1.

1 reference

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12 July 2018

Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice

1 reference

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12 July 2018

Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse

1 reference

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12 July 2018

EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts

1 reference

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12 July 2018

Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

12 July 2018

Signal transduction pathways involved in mechanotransduction in bone cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

12 July 2018

Fluid shear stress synergizes with insulin-like growth factor-I (IGF-I) on osteoblast proliferation through integrin-dependent activation of IGF-I mitogenic signaling pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

12 July 2018

Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation

1 reference

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12 July 2018

The impact of skeletal unloading on bone formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

12 July 2018

Parathyroid hormone induces the nuclear orphan receptor NOR-1 in osteoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

12 July 2018

Calcium regulates the PI3K-Akt pathway in stretched osteoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

12 July 2018

A time course of bone response to jump exercise in C57BL/6J mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

12 July 2018

Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

12 July 2018

Effects of recombinant insulin-like growth factor-binding protein-4 on bone formation parameters in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

12 July 2018

Mechanical loading stimulates rapid changes in periosteal gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

12 July 2018

Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

26 September 2018

Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

26 September 2018

Effect of mechanical loading on insulin-like growth factor-I gene expression in rat tibia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

26 September 2018

Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

26 September 2018

Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

26 September 2018

Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

26 September 2018

Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

26 September 2018

Bone anabolic responses to mechanical load in vitro involve COX-2 and constitutive NOS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

26 September 2018

Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

26 September 2018

Skeletal unloading induces resistance to insulin-like growth factor I on bone formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

26 September 2018

Mechanical Loading Stimulates Dentin Matrix Protein 1 (DMP1) Expression in Osteocytes In Vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233773

26 September 2018

Mechanical loading by fluid shear stress enhances IGF-1 receptor signaling in osteoblasts in a PKCzeta-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/21878662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21878662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of exercise on systemic and bone concentrations of growth factors in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21878662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of dynamic axial loading on the rat growth plate

1 reference

https://pubmed.ncbi.nlm.nih.gov/21878662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanotransduction in the cortical bone is most efficient at loading frequencies of 5-10 Hz

1 reference

https://pubmed.ncbi.nlm.nih.gov/21878662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21878662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21878662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteocytic expression of mRNA for c-fos and IGF-I: an immediate early gene response to an osteogenic stimulus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21878662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone response to in vivo mechanical loading in two breeds of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21878662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/21878662

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPENDO.00440.2011

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21878662%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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24 November 2022

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11 February 2020

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Europe PubMed Central

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11 February 2020

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